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The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance
TLDR
It appears that the spatial and temporal expression of NTPDases by various cell types within the vasculature, the nervous tissues and other tissues impacts on several patho-physiological processes.
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Extracellular metabolism of ATP and other nucleotides
  • H. Zimmermann
  • Biology
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 19 August 2000
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Cellular function and molecular structure of ecto-nucleotidases
TLDR
The review focuses on the principal biochemical, cell biological, catalytic, and structural properties of the enzymes and provides brief reference to tissue distribution, and physiological and pathophysiological functions.
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Purinergic signalling in the nervous system: an overview
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5'-Nucleotidase: molecular structure and functional aspects.
TLDR
The present review suggests a classification and divides the vertebrate 5'-nucleotidases into four distinct groups according to biochemical properties and cellular location.
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Ectonucleotidases: Some recent developments and a note on nomenclature
TLDR
Members of the various ectonucleotidase families reveal overlapping substrate specificity and tissue distribution whose functional significance needs to be further elucidated, leading to a deeper understanding of the pathways of extracellular nucleotide metabolism.
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BIOCHEMISTRY, LOCALIZATION AND FUNCTIONAL ROLES OF ECTO-NUCLEOTIDASES IN THE NERVOUS SYSTEM
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Signalling via ATP in the nervous system
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Ectonucleotidases in the nervous system.
TLDR
Members of several families of ectonucleotidases can contribute to extracellular nucleotide hydrolysis and proposed physiological functions include modulation of synaptic transmission, of the ATP-mediated propagation of glial Ca2+ waves, of microglial function, adult neurogenesis or the control of vascular tone, haemostasis and thromboregulation.
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Distribution of ectonucleotidases in the rodent brain revisited
TLDR
A comparative analysis of the overall distribution of catalytic activities reflecting four ectonucleotidase families is provided, for the first time, and novel evidence for a parenchymal localization of tissue non-specific alkaline phosphatase, E-NPPs, and E-NTPDases in the mouse brain is provided.
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