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- Publications
- Influence
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance
- S. Robson, J. Sévigny, H. Zimmermann
- Biology, Medicine
- Purinergic Signalling
- 30 May 2006
Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been… Expand
Cellular function and molecular structure of ecto-nucleotidases
- H. Zimmermann, M. Zebisch, N. Sträter
- Biology, Medicine
- Purinergic Signalling
- 4 May 2012
Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze extracellular nucleotides and thus can control their availability at purinergic P2 receptors. They generate… Expand
Extracellular metabolism of ATP and other nucleotides
- H. Zimmermann
- Chemistry, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 19 August 2000
Purinergic signalling in the nervous system: an overview
- M. Abbracchio, G. Burnstock, A. Verkhratsky, H. Zimmermann
- Biology, Medicine
- Trends in Neurosciences
- 2009
Purinergic receptors, represented by several families, are arguably the most abundant receptors in living organisms and appeared early in evolution. After slow acceptance, purinergic signalling in… Expand
Ectonucleotidases: Some recent developments and a note on nomenclature
- H. Zimmermann
- Biology
- 2001
Extracellular nucleotides such as ATP, ADP, UTP, UDP, and also diadenosine polyphosphates act as signaling molecules and can be inactivated by hydrolysis via ectonucleotidases. A considerable number… Expand
5'-Nucleotidase: molecular structure and functional aspects.
- H. Zimmermann
- Biology, Medicine
- The Biochemical journal
- 15 July 1992
5'-Nucleotidase activity was first described in heart and skeletal muscle about 60 years ago (Reis, 1934). It catalyses the hydrolysis of phosphate esterified at carbon 5' of the ribose and… Expand
BIOCHEMISTRY, LOCALIZATION AND FUNCTIONAL ROLES OF ECTO-NUCLEOTIDASES IN THE NERVOUS SYSTEM
- H. Zimmermann
- Biology, Medicine
- Progress in Neurobiology
- 1 August 1996
Nucleotides such as ATP, ADP, UTP or the diadenosine polyphosphates and possibly even NAD+ are extracellular signaling substances in the brain and in other tissues. Enzymes located on the cell… Expand
Signalling via ATP in the nervous system
- H. Zimmermann
- Biology, Medicine
- Trends in Neurosciences
- 1994
Strong evidence has been provided that ATP can act as a transmitter not only in smooth muscle but also in peripheral ganglia and in brain. The cloning and molecular identification of two putative ATP… Expand
Ectonucleotidases in the nervous system.
- H. Zimmermann
- Chemistry, Medicine
- Novartis Foundation symposium
- 7 October 2008
Extracellular nucleotides are hydrolysed by enzymes of the plasma membrane with an extracellularly oriented catalytic site (ectonucleotidases). Members of several families of ectonucleotidases can… Expand
Distribution of ectonucleotidases in the rodent brain revisited
- D. Langer, K. Hammer, P. Koszałka, J. Schrader, S. Robson, H. Zimmermann
- Biology, Medicine
- Cell and Tissue Research
- 9 October 2008
Nucleotides comprise a major class of signaling molecules in the nervous system. They can be released from nerve cells, glial cells, and vascular cells where they exert their function via ionotropic… Expand
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