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The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance
Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have beenExpand
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Cellular function and molecular structure of ecto-nucleotidases
Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze extracellular nucleotides and thus can control their availability at purinergic P2 receptors. They generateExpand
  • 615
  • 73
Extracellular metabolism of ATP and other nucleotides
  • H. Zimmermann
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 19 August 2000
  • 923
  • 64
Purinergic signalling in the nervous system: an overview
Purinergic receptors, represented by several families, are arguably the most abundant receptors in living organisms and appeared early in evolution. After slow acceptance, purinergic signalling inExpand
  • 692
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  • PDF
Ectonucleotidases: Some recent developments and a note on nomenclature
Extracellular nucleotides such as ATP, ADP, UTP, UDP, and also diadenosine polyphosphates act as signaling molecules and can be inactivated by hydrolysis via ectonucleotidases. A considerable numberExpand
  • 424
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5'-Nucleotidase: molecular structure and functional aspects.
  • H. Zimmermann
  • Biology, Medicine
  • The Biochemical journal
  • 15 July 1992
5'-Nucleotidase activity was first described in heart and skeletal muscle about 60 years ago (Reis, 1934). It catalyses the hydrolysis of phosphate esterified at carbon 5' of the ribose andExpand
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BIOCHEMISTRY, LOCALIZATION AND FUNCTIONAL ROLES OF ECTO-NUCLEOTIDASES IN THE NERVOUS SYSTEM
  • H. Zimmermann
  • Biology, Medicine
  • Progress in Neurobiology
  • 1 August 1996
Nucleotides such as ATP, ADP, UTP or the diadenosine polyphosphates and possibly even NAD+ are extracellular signaling substances in the brain and in other tissues. Enzymes located on the cellExpand
  • 429
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Signalling via ATP in the nervous system
Strong evidence has been provided that ATP can act as a transmitter not only in smooth muscle but also in peripheral ganglia and in brain. The cloning and molecular identification of two putative ATPExpand
  • 441
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Ectonucleotidases in the nervous system.
  • H. Zimmermann
  • Chemistry, Medicine
  • Novartis Foundation symposium
  • 7 October 2008
Extracellular nucleotides are hydrolysed by enzymes of the plasma membrane with an extracellularly oriented catalytic site (ectonucleotidases). Members of several families of ectonucleotidases canExpand
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Distribution of ectonucleotidases in the rodent brain revisited
Nucleotides comprise a major class of signaling molecules in the nervous system. They can be released from nerve cells, glial cells, and vascular cells where they exert their function via ionotropicExpand
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