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Non-nucleoside inhibitors of HIV-1 reverse transcriptase: molecular modeling and X-ray structure investigations.
The structural features of a new class of non-nucleoside HIV-1 reverse transcriptase inhibitors (3) are presented. Comparison of the structural and electronic properties with those of TIBO (1) andExpand
Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes.
In an attempt to assess the structural requirements of hexahydro-sila-difenidol for potency and selectivity, a series of analogues modified in the amino group and the phenyl ring were investigatedExpand
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity.
A series of substituted 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds 1-73 were synthesized and evaluated for their ability to inhibit reverse transcriptase (RT) of the humanExpand
Binding and functional properties of antimuscarinics of the hexocyclium/sila‐hexocyclium and hexahydro‐diphenidol/hexahydro‐sila‐diphenidol type to muscarinic receptor subtypes
1 In an attempt to assess the structural requirements for the muscarinic receptor selectivity of hexahydro‐diphenidol (hexahydro‐difenidol) and hexahydro‐sila‐diphenidol (hexahydro‐sila‐difenidol), aExpand
Sila-substitution--a useful strategy for drug design?
Abstract Sila-substitution (C/Si-exchange) of drugs is one of the approaches currently used in the search for new biologically active organosilicon compounds. Replacement of specific carbon atoms inExpand
Enantioselective microbial reduction of 1,1-dimethyl-1-sila-cyclohexan-2-one with growing cells of the yeast Kloeckera corticis (ATCC 20109)
(R)-1,1-Dimethyl-1-sila-cyclohexan-2-ol [(R)-2] was prepared by enantioselective microbial reduction of 1,1-dimethyl-1-sila-cyclohexan-2-one (1) with growing cells of the yeast Kloeckera corticisExpand
Enantioselective reduction of acetyldimethylphenylsilane by Trigonopsis variabilis (DSM 70714)
SummaryGrowing and resting cells of the yeast Trigonopsis variabilis (DSM 70714) can be used for the enantioselective reduction of the organosilicon compound acetyldimethylphenylsilane (1) to giveExpand
A study of the bile pigments and related compounds in solution by 13C nuclear magnetic resonance spectroscopy
The natural abundance 13C n.m.r. spectra of six bile pigments and several related compounds are reported. Two of the former, namely mesobiliverdin-IXα dimethyl ester (11) and mesobilirubin-IXαExpand
Biotransformation as a New Method for Preparing Optically Active Organometallic Compounds a
Trois methodes de preparation des silanes et des germanes optiquement actifs sont utilisees. Elles font appel a des reductions enantioselectives par des micro-organismes (levure TrigonopsisExpand