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Reaction of antimalarial endoperoxides with specific parasite proteins.
The endoperoxides are a new class of antimalarial agents, of which artemisinin (qinghaosu) is the prototype. We have previously shown that artemisinin is capable of alkylating proteins in modelExpand
Evidence for an enantioselective pumiliotoxin 7-hydroxylase in dendrobatid poison frogs of the genus Dendrobates
Dendrobatid poison frogs readily accumulate alkaloids from diet into skin, where such compounds serve as a chemical defense against predators. Arthropods seem to be the source of decahydroquinolinesExpand
Beauveria Sulfurescens Mediated Oxidation of Dihydroartemisinin Derivatives
Artemisinin, a sesquiterpene which contains a labile endo-peroxide, is a promising new antimalarial drug. In order to prepare new derivatives that retain the peroxide group critical for biologicalExpand
Fluorescence of tryptophan dipeptides: correlations with the rotamer model.
The multiexponential decay of tryptophan derivatives has previously been explained by the presence of rotamers having different fluorescence lifetimes, but it has been difficult to correlate rotamerExpand
Pantothenic Acid, Thiamine and Folic Acid Levels at Parturition.∗
Summary A comparison of pantothenic acid, thiamine, and PGA serum levels of mothers and infants at parturition shows an approximately 5-fold increase of these vitamins in the fetal circulation. TheExpand
Syntheses and antimalarial activities of N-substituted 11-azaartemisinins.
A two-step reaction sequence between artemisinin and methanolic ammonia followed by treatment with Amberlyst 15 yielded 11-azaartemisinin in 65% yield. Substituting a variety of primary alkyl- andExpand
Syntheses and antimalarial activities of 10-substituted deoxoartemisinins.
Two series of 10-substituted deoxoartemisinin derivatives have been synthesized. The first employed the reaction of dihydroartemisinin acetate with several silyl enol ethers in the presence ofExpand