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Increased vascularization in mice overexpressing angiopoietin-1.
The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular endothelial cells. Targeted geneExpand
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Zebrafish Dpr2 Inhibits Mesoderm Induction by Promoting Degradation of Nodal Receptors
Nodal proteins, members of the transforming growth factor–β (TGFβ) superfamily, have been identified as key endogenous mesoderm inducers in vertebrates. Precise control of Nodal signaling isExpand
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Interaction and Feedback Regulation between STK15/BTAK/Aurora-A Kinase and Protein Phosphatase 1 through Mitotic Cell Division Cycle*
STK15 is an Aurora/Ipl-1 related serine/threonine kinase that is associated with centrosomes and induces aneuploidy when overexpressed in mammalian cells. It is well known that phosphorylation andExpand
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The Akt Proto-oncogene Links Ras to Pak and Cell Survival Signals*
The Ras oncogene regulates cellular proliferation, differentiation, transformation, and survival through multiple downstream signals. Ras signals through its effector phosphoinositide 3 (PI3) kinaseExpand
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NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.
Nonsteroidal anti-inflammatory drugs (NSAIDs) exert their anticancer effects through cyclooxygenase-2 (COX-2)-dependent and independent mechanisms. Here, we report that Sulindac, an NSAID, inducesExpand
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Missense Mutation in APOC3 within the C-terminal Lipid Binding Domain of Human ApoC-III Results in Impaired Assembly and Secretion of Triacylglycerol-rich Very Low Density Lipoproteins
Hepatic assembly of triacylglycerol (TAG)-rich very low density lipoproteins (VLDL) is achieved through recruitment of bulk TAG (presumably in the form of lipid droplets within the microsomal lumen)Expand
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Advancements in top-down proteomics.
Advancements in Top-Down Proteomics Hu Zhou, Zhibing Ning, Amanda E. Starr, Mohamed Abu-Farha, and Daniel Figeys* Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology andExpand
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Localized-Statistical Quantification of Human Serum Proteome Associated with Type 2 Diabetes
Background Recent advances in proteomics have shed light to discover serum proteins or peptides as biomarkers for tracking the progression of diabetes as well as understanding molecular mechanisms ofExpand
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Inhibition of β-catenin Signaling by Nongenomic Action of Orphan Nuclear Receptor Nur77
Dysregulation of β-catenin turnover due to mutations of its regulatory proteins including adenomatous polyposis coli (APC) and p53 is implicated in the pathogenesis of cancer. Thus, intensive effortExpand
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Regulation of Septin Dynamics by the Saccharomyces cerevisiae Lysine Acetyltransferase NuA4
In the budding yeast Saccharomyces cerevisiae, the lysine acetyltransferase NuA4 has been linked to a host of cellular processes through the acetylation of histone and non-histone targets. ToExpand
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