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Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
The synthesis and structure-activity relationship of a novel series of compounds with combined effects on 5-HT(3A) and 5-HT(1A) receptors and on the serotonin (5-HT) transporter (SERT) are described.Expand
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Small molecule antagonists of melanopsin-mediated phototransduction
Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation to ambient light and other non-image forming photic responses. This has raised the possibility thatExpand
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Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action
RationaleEscitalopram is a widely used antidepressant for the treatment of patients with major depression. It is the pure S-enantiomer of racemic citalopram. Several clinical trials and meta-analysesExpand
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An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: Kinetic binding studies with the ALI/VFL–SI/TT mutant
The human serotonin transporter (hSERT) has primary and allosteric binding sites for escitalopram and R-citalopram. Previous studies have established that the interaction of these two compounds at aExpand
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The effects of 5′-N-ethylcarboxamidoadenosine on evoked release of [3H]serotonin in the rat nucleus tractus solitarius
5'-N-Ethylcarboxamidoadenosine (NECA) a non-selective adenosine A1 and A2a receptor agonist was employed in stimulated (3 Hz, 25 mA, 1 min) superfused nucleus tractus solitarius (NTS) brain slicesExpand
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Use of Caenorhabditis elegans G{alpha}q chimeras to detect G-protein-coupled receptor signals.
G-protein-coupled receptors (GPCRs) activate heterotrimeric G-proteins (G(i)-, G(s)-, G(q)-, or G(12)-like) to generate specific intracellular responses, depending on the receptor/G-protein coupling.Expand
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(8‐Quinolinol‐κ2N,O)bis­(8‐quinolinolato‐κ2N,O)zinc(II) glyoxal hemisolvate monohydrate
The ZnII atom in the title complex, [Zn(C9H6NO)2(C9H7NO)]·0.5C2H2O2·H2O, exists in an octa­hedral coordination geometry defined by three O and three N atoms from three 8-hydroxy­quinoline ligands.Expand
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Aqua­chloro­bis(1,10‐phenanthroline)nickel(II) chloride thio­acetamide solvate
The Ni atom in the cation of the title complex, [NiCl(C12H8N2)2(H2O)]Cl·C2H5NS, has a distorted octa­hedral coordination geometry defined by a Cl atom, the O atom of a water mol­ecule, and four NExpand
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