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CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes
Recognition of sweet, bitter and umami tastes requires the non-vesicular release from taste bud cells of ATP, which acts as a neurotransmitter to activate afferent neural gustatory pathways. However,Expand
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AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism*
Alzheimer disease is an age-related neurodegenerative disorder characterized by amyloid-β (Aβ) peptide deposition into cerebral amyloid plaques. The natural polyphenol resveratrol promotes anti-agingExpand
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Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides*
Several epidemiological studies indicate that moderate consumption of wine is associated with a lower incidence of Alzheimer's disease. Wine is enriched in antioxidant compounds with potentialExpand
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Resveratrol mitigates lipopolysaccharide‐ and Aβ‐mediated microglial inflammation by inhibiting the TLR4/NF‐κB/STAT signaling cascade
J. Neurochem. (2012) 120, 461–472.
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Inhibition of AMP-Activated Protein Kinase Signaling Alleviates Impairments in Hippocampal Synaptic Plasticity Induced by Amyloid β
The AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that is activated in response to low-energy states to coordinate multiple signaling pathways to maintain cellular energy homeostasis.Expand
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Novel synthetic small‐molecule activators of AMPK as enhancers of autophagy and amyloid‐β peptide degradation
AMP‐activated protein kinase (AMPK) is a metabolic sensor involved in intracellular energy metabolism through the control of several homeostatic mechanisms, which include autophagy and proteinExpand
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Acute Regulation of Na+/H+ Exchanger NHE3 by Parathyroid Hormone via NHE3 Phosphorylation and Dynamin-dependent Endocytosis*
Parathyroid hormone (PTH) is a potent inhibitor of mammalian renal proximal tubule Na+transport via its action on the apical membrane Na+/H+ exchanger NHE3. In the opossum kidney cell line,Expand
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Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK), RSVA314 and RSVA405, Inhibit Adipogenesis
AMP-activated protein kinase (AMPK) is a sensor and regulator of cellular energy metabolism potentially Implicated In a broad range of conditions, including obesity and Alzheimer’s disease. Its roleExpand
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CALHM1 controls the Ca2+-dependent MEK, ERK, RSK and MSK signaling cascade in neurons
Summary Calcium homeostasis modulator 1 (CALHM1) is a Ca2+ channel controlling neuronal excitability and potentially involved in the pathogenesis of Alzheimer's disease (AD). Although strong evidenceExpand
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AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
Neurofibrillary tangles (NFTs) are the pathological hallmark of neurodegenerative diseases commonly known as tauopathies. NFTs result from the intracellular aggregation of abnormally andExpand
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