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Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells
Astaxanthin (ATX), the most abundant flavonoids in propolis, has been proven to exert neuroprotective property against glutamate-induced neurotoxicity and ischemia-reperfusion-induced apoptosis.Expand
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Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression
The aim of this study was to investigate sonic hedgehog (SHH) signaling pathway components (Shh and Gli-1), E-cadherin, and MMP-9 expression in human oral squamous cell carcinoma (OSCC) and toExpand
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Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species.
Postoperative chemotherapy for Colorectal cancer (CRC) patients is not all effective and the main reason might lie in cancer stem cells (CSCs). Emerging studies showed that CSCs overexpress someExpand
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Effects of testosterone and 17-β-estradiol on TNF-α-induced E-selectin and VCAM-1 expression in endothelial cells
Abstract This study investigated the effects of testosterone and 17-β-estradiol on tumor necrosis factor-alpha (TNF-α)-induced endothelial expression of E-selectin and vascular cell adhesionExpand
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Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.
Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. OurExpand
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TBX20 loss-of-function mutation contributes to double outlet right ventricle.
Congenital heart disease (CHD), the most prevalent birth defect in humans worldwide, is still a leading non‑infectious cause of infant morbidity and mortality. Increasing evidence demonstrates thatExpand
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The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability.
The fate of disseminated tumor cells is largely determined by microenvironment (ME) niche. The osteogenic niche promotes cancer cell proliferation and bone metastasis progression. We investigated theExpand
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Ghrelin inhibits apoptosis induced by palmitate in rat aortic endothelial cells.
BACKGROUND Ghrelin is the endogenous ligand of the growth hormone secretagogue receptor. It has been reported to have cardiovascular protective activities. Elevated plasma free fatty acids triggerExpand
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Agonist-mediated Ca2' Release in Permeabilized UMR- 106-O 1 Cells
Permeabilized and intact UMR-106-01 cells at- tached to culture plates or coverslips were used to evaluate compartmentalized generation and the effec- tive concentration of inositolExpand
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Analysis of Cellular DNA Content by Flow Cytometry
Cellular DNA content can be measured by flow cytometry with the aim of : (1) revealing cell distribution within the major phases of the cell cycle, (2) estimating frequency of apoptotic cells withExpand
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