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Telomere dysfunction: a potential cancer predisposition factor.
TLDR
Telomere length was statistically significantly and inversely associated with baseline and mutagen-induced genetic instability and appears to be associated with increased risks for human bladder, head and neck, lung, and renal cell cancers.
p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity.
TLDR
Genotype and haplotype frequency distributions were strongly dependent on ethnicity; variant allele frequencies were highest in African-Americans (29.1%) and lowest in Mexican-American (12.2%).
An Extensive Field Survey Combined with a Phylogenetic Analysis Reveals Rapid and Widespread Invasion of Two Alien Whiteflies in China
TLDR
Assessment of the current diversity and distribution of B. tabaci cryptic species in China shows that whereas in the past the exotic invader Middle East-Asia Minor 1 was predominant across China, another newer invader Mediterranean is now the dominant species in the Yangtze River Valley and eastern coastal areas, and Middle East, Asia Minor 1 is now predominant only in the south and south eastern Coastal areas.
A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis.
TLDR
The data suggest that breast/ovarian cancer patients with variant C allele miR-146a may have high levels of mature miR -146 and that these variants predispose them to an earlier age of onset of familial breast and ovarian cancers.
XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity.
TLDR
The data suggest that the XPA 5' non-coding region polymorphism modulates NER capacity and is associated with decreased lung cancer risk, especially in the presence of exposure to tobacco carcinogens.
Nucleotide Excision Repair Gene Polymorphisms and Recurrence after Treatment for Superficial Bladder Cancer
TLDR
The data suggest that interindividual differences in DNA repair capacity may have an important impact on superficial bladder cancer recurrence, and a pathway-based approach is preferred to study the effects of individual polymorphism on clinical outcomes.
Serum levels of insulin-like growth factor I and risk of squamous intraepithelial lesions of the cervix.
TLDR
Serum levels of IGF-I may be a useful biomarker for assessing risk of Sils development, and there was a dose-response relationship between risk of SILs and the level of IGF/ IGFBP-3: as the levelof IGF/I increased, so did the risk ofsils.
Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae
TLDR
A total of 14 constitutive promoters from S. cerevisiae were cloned and characterized using a green fluorescent protein (GFP) as a reporter in a 2 µ vector pRS426, under varying glucose and oxygen concentrations, with promoter TEF1p being the strongest and promoter PGI1p the weakest.
A Pilot Study of Circulating miRNAs as Potential Biomarkers of Early Stage Breast Cancer
TLDR
The observations from this pilot study suggest that the altered levels of circulating miRNAs might have great potential to serve as novel, noninvasive biomarkers for early detection of breast cancer.
Association between indel polymorphism in the promoter region of lncRNA GAS5 and the risk of hepatocellular carcinoma.
TLDR
Evidence is provided that a 5-base pair indel polymorphism in the promoter region of GAS5 with hepatocelluar carcinoma (HCC) susceptibility in Chinese populations may contribute to hepatocarcinogenesis by affecting methylation status of the GAS 5 promoter and subsequently its transcriptional activity thus serving as a potential therapy target for HCC.
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