• Publications
  • Influence
The coordinate regulation of the p53 and mTOR pathways in cells.
Cell growth and proliferation requires an intricate coordination between the stimulatory signals arising from nutrients and growth factors and the inhibitory signals arising from intracellular andExpand
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The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
The transcription factor ATF4 regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER stress responses, and it is overexpressed in human solid tumours,Expand
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miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1.
Epithelial-to-mesenchymal transition (EMT) has been implicated in embryonic development and various pathological events. Snail1 is a well-known E-cadherin-transcriptional repressor that isExpand
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Arabidopsis R-SNARE Proteins VAMP721 and VAMP722 Are Required for Cell Plate Formation
Background Cell plate formation during plant cytokinesis is facilitated by SNARE complex-mediated vesicle fusion at the cell-division plane. However, our knowledge regarding R-SNARE components ofExpand
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Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness
Rationale Medical masks are commonly used by sick individuals with influenza-like illness (ILI) to prevent spread of infections to others, but clinical efficacy data are absent. Objective DetermineExpand
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mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
Precise coordination of cell growth, proliferation and differentiation is essential for the development of multicellular organisms. Here, we report that although the mechanistic target of rapamycinExpand
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KPNB1, XPO7 and IPO8 Mediate the Translocation ofNF‐κB/p65 into the Nucleus
NF‐κB/p65 is retained in the cytoplasm until it is activated in response to stress. Nuclear import of p65 is regulated by importin α in a nuclear localization signal (NLS)‐dependent manner. However,Expand
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A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice
Here, we report the creation of a single-helix peptide (ATI-5261) that stimulates cellular cholesterol efflux with Km molar efficiency approximating native apolipoproteins. Anti-atherosclerosisExpand
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Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study
Objectives The irreversible airflow limitation characterised by chronic obstructive pulmonary disease (COPD) causes a decrease in the oxygen supply to the brain. The aim of the present study was toExpand
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Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling.
  • A. Chung, H. Zhang, +4 authors H. Lan
  • Biology, Medicine
  • Journal of the American Society of Nephrology…
  • 1 February 2010
Advanced glycation end-products (AGEs) can induce expression of connective tissue growth factor (CTGF), which seems to promote the development of diabetic nephropathy, but the exact signalingExpand
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