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MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia
A new pathway that miR-100 regulates G1/S transition and S-phase entry and blocks the terminal differentiation by targeting RBSP3, which partly in turn modulates the cell cycle effectors pRB/E2F1 in AML is revealed. Expand
The DNA methylation-regulated miR-193a-3p dictates the multi-chemoresistance of bladder cancer via repression of SRSF2/PLAU/HIC2 expression
This study provides a new set of diagnostic targets for the guided personalized chemotherapy of bladder cancer with mechanistic insights in how the newly identified miR-193a-3p/SRSF2, PLAU,HIC2/five signaling pathway axis regulates the chemoresistance of bladdercancer cells. Expand
CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation
  • J. Liu, C. Gao, +16 authors Z. Li
  • Biology, Medicine
  • Translational psychiatry
  • 1 January 2016
The findings fill the gap of knowledge regarding the relationship between SCN1A mutation effect recorded on exogenously transfected cells and on Nav1.1-expressing neurons, and reveal the physiological basis underlying epileptogenesis caused by SCN 1A loss-of-function mutation. Expand
Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule
Collectively, these data provide the first evidence that a therapeutically used drug targets the surface diffusion of AMPAR through a CaMKII–stargazin–PSD-95 pathway, to promote long-term synaptic plasticity. Expand
Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
In vitro and in vivo effects of metformin on esophageal squamous cell carcinoma (ESCC) cells are investigated, finding that inactivation of Stat3-Bcl-2 pathway contributes to meetformin-induced growth inhibition of ESCC by facilitating crosstalk between apoptosis and autophagy. Expand
39-GHz optoelectronic oscillator using broad-band polymer electrooptic modulator
An optoelectronic oscillator (OEO) producing a 39-GHz microwave signal has been demonstrated using a novel electrode-poled push-pull polymer modulator. This is the highest reported OEO operatingExpand
Altered brain arginine metabolism in schizophrenia
Evidence is provided of altered brain arginine metabolism in schizophrenia, which enhances the authors' understanding of the pathogenesis of schizophrenia and may lead to the future development of novel preventions and/or therapeutics for the disease. Expand
Notch1 activation is a poor prognostic factor in patients with gastric cancer
Notch1 activation was correlated with gastric cancer progression and defined as a novel independent prognostic factor, which could be incorporated into the TNM system to generate a better predictive model for patient outcomes. Expand
PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2
It is shown that reexpression of PTPRO may be a potential therapy for ERBB2-overexpressing breast cancer through dephosphorylation leading to dual effects of ERBB 2 signaling suppression and endosomal internalization of ER BB2. Expand
Autophagy collaborates with ubiquitination to downregulate oncoprotein E2A/Pbx1 in B-cell acute lymphoblastic leukemia
It is shown that activation of autophagy by preventive administration of rapamycin improved the survival of leukemia animals by partial restoration of hematopoietic stem/progenitor cells, whereas treatment of the animals with Rapamycin caused leukemia bone marrow cell-cycle arrest. Expand