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Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
- A. Cantrell, P. Engelhardt, +17 authors H. Zhang
- Chemistry, Medicine
- Journal of medicinal chemistry
- 11 October 1996
Phenylethylthiazolylthiourea (PETT) derivatives have been identified as a new series of non-nucleoside inhibitors of HIV-1 RT. Structure-activity relationship studies of this class of compounds… Expand
Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma
BackgroundHeat shock-related 70 kDa protein 2 (HSPA2) has been identified as a potential cancer-promoting protein expressed at abnormal levels in a subset of cancers. However, its important role in… Expand
Evaluation of Acute Toxicity of Essential Oil of Garlic (Allium sativum) and Its Selected Major Constituent Compounds Against Overwintering Cacopsylla chinensis (Hemiptera: Psyllidae)
- N. N. Zhao, H. Zhang, +5 authors Z. L. Liu
- Biology, Medicine
- Journal of economic entomology
- 10 June 2013
ABSTRACT In our screening program for insecticidal activity of the essential oils/extracts derived from some Chinese medicinal herbs and spices, garlic (Allium sativum L.) essential oil was found… Expand
Dinuclear metal(II) complexes of polybenzimidazole ligands as carriers for DNA delivery.
A metal-based nonviral carrier for DNA-transfer in gene therapy was synthesized and characterized. The strong intermolecular pi-pi contacts are common in the observed dinuclear Cu(2+) and Co(2+)… Expand
Visualizing electrical breakdown and ON/OFF states in electrically switchable suspended graphene break junctions.
Narrow gaps are formed in suspended single- to few-layer graphene devices using a pulsed electrical breakdown technique. The conductance of the resulting devices can be programmed by the application… Expand
The dual roles of oxodiperoxovanadate both as a nucleophile and an oxidant in the green oxidation of benzyl alcohols or benzyl halides to aldehydes and ketones.
A Nanosystem Capable of Releasing a Photosensitizer Bioprecursor under Two‐Photon Irradiation for Photodynamic Therapy
- Hao Wu, Fang Zeng, H. Zhang, Jiangsheng Xu, J. Qiu, S. Wu
- Materials Science, Medicine
- Advanced science
- 25 November 2015
The applications of photodynamic therapy (PDT) are usually limited by photosensitizers' side effects and singlet oxygen's short half‐life. Herein, a mitochondria‐targeted nanosystem is demonstrated… Expand
Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery
Microtubules are dynamic assemblies of αβ‐tubulin heterodimers and have been recognized as highly attractive targets for cancer chemotherapy. A broad range of agents bind to tubulin and interfere… Expand
Synthesis, crystal structure, cytotoxic activity and DNA-binding properties of the copper (II) and zinc (II) complexes with 1-[3-(2-pyridyl)pyrazol-1-ylmethyl]naphthalene.
- H. Zhang, Chunsen Liu, X. Bu, Ming Yang
- Chemistry, Medicine
- Journal of inorganic biochemistry
- 1 May 2005
A new ligand L, 1-[3-(2-pyridyl)pyrazol-1-ylmethyl]naphthalene, and its two metal complexes, [Cu(L)3](ClO4)2 (1) and [Zn(L)3](ClO4)2(H2O)2 (2), have been synthesized and characterized. The crystal… Expand
Ultrasensitive Detection of MicroRNAs with Morpholino-Functionalized Nanochannel Biosensor.
Here, we demonstrate a phosphorodiamidate morpholino oligos (PMO)-functionalized nanochannel biosensor for label-free detection of microRNAs (miRNAs) with ultrasensitivity and high sequence… Expand