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Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
Phenylethylthiazolylthiourea (PETT) derivatives have been identified as a new series of non-nucleoside inhibitors of HIV-1 RT. Structure-activity relationship studies of this class of compoundsExpand
Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma
BackgroundHeat shock-related 70 kDa protein 2 (HSPA2) has been identified as a potential cancer-promoting protein expressed at abnormal levels in a subset of cancers. However, its important role inExpand
Evaluation of Acute Toxicity of Essential Oil of Garlic (Allium sativum) and Its Selected Major Constituent Compounds Against Overwintering Cacopsylla chinensis (Hemiptera: Psyllidae)
ABSTRACT In our screening program for insecticidal activity of the essential oils/extracts derived from some Chinese medicinal herbs and spices, garlic (Allium sativum L.) essential oil was foundExpand
Dinuclear metal(II) complexes of polybenzimidazole ligands as carriers for DNA delivery.
A metal-based nonviral carrier for DNA-transfer in gene therapy was synthesized and characterized. The strong intermolecular pi-pi contacts are common in the observed dinuclear Cu(2+) and Co(2+)Expand
Visualizing electrical breakdown and ON/OFF states in electrically switchable suspended graphene break junctions.
Narrow gaps are formed in suspended single- to few-layer graphene devices using a pulsed electrical breakdown technique. The conductance of the resulting devices can be programmed by the applicationExpand
A Nanosystem Capable of Releasing a Photosensitizer Bioprecursor under Two‐Photon Irradiation for Photodynamic Therapy
The applications of photodynamic therapy (PDT) are usually limited by photosensitizers' side effects and singlet oxygen's short half‐life. Herein, a mitochondria‐targeted nanosystem is demonstratedExpand
Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery
Microtubules are dynamic assemblies of αβ‐tubulin heterodimers and have been recognized as highly attractive targets for cancer chemotherapy. A broad range of agents bind to tubulin and interfereExpand
Synthesis, crystal structure, cytotoxic activity and DNA-binding properties of the copper (II) and zinc (II) complexes with 1-[3-(2-pyridyl)pyrazol-1-ylmethyl]naphthalene.
A new ligand L, 1-[3-(2-pyridyl)pyrazol-1-ylmethyl]naphthalene, and its two metal complexes, [Cu(L)3](ClO4)2 (1) and [Zn(L)3](ClO4)2(H2O)2 (2), have been synthesized and characterized. The crystalExpand
Ultrasensitive Detection of MicroRNAs with Morpholino-Functionalized Nanochannel Biosensor.
Here, we demonstrate a phosphorodiamidate morpholino oligos (PMO)-functionalized nanochannel biosensor for label-free detection of microRNAs (miRNAs) with ultrasensitivity and high sequenceExpand