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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.
  • H. Sun, R. Lesche, +7 authors H. Wu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 25 May 1999
To investigate the molecular basis of PTEN-mediated tumor suppression, we introduced a null mutation into the mouse Pten gene by homologous recombination in embryonic stem (ES) cells. Pten-/- ESExpand
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Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
  • Z. Li, J. Lu, +18 authors J. Chen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 7 October 2008
MicroRNAs (miRNAs) are postulated to be important regulators in cancers. Here, we report a genome-wide miRNA expression analysis in 52 acute myeloid leukemia (AML) samples with common translocations,Expand
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Phycobilisomes Supply Excitations to Both Photosystems in a Megacomplex in Cyanobacteria
Complexing Photosynthesis Photosynthesis operates through a series of protein complexes that harvest sunlight and turn it into chemical energy. The separate complexes—including photosystems I and II,Expand
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MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
  • S. Mi, J. Lu, +13 authors J. Chen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 11 December 2007
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, whereas acute myeloid leukemia (AML) is the most common acute leukemia in adults. In general, ALL has a better prognosis thanExpand
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Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
Side-population (SP) cells within cancers and cell lines are rare cell populations known to enrich cancer stem-like cells. In this study, we characterized SP cells from the human breast cancer cellExpand
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Co-contamination of aflatoxin B1 and fumonisin B1 in food and human dietary exposure in three areas of China
  • G. Sun, S. Wang, +6 authors J. Wang
  • Biology, Medicine
  • Food additives & contaminants. Part A, Chemistry…
  • 22 January 2011
Aflatoxins and fumonisins are ubiquitous foodborne toxicants and the co-occurrence of these mycotoxins in human foods represents a significant public health concern, which has been stronglyExpand
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Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remainsExpand
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Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State
The intracellular pathogen Legionella pneumophila hijacks the endoplasmic reticulum (ER)-derived vesicles to create an organelle designated Legionella-containing vacuole (LCV) required for bacterialExpand
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Effect of exogenous spermidine on polyamine content and metabolism in tomato exposed to salinity-alkalinity mixed stress.
We investigated the effects of seeds pretreatment with exogenous spermidine (Spd) on the polyamine content and metabolism in the roots of two cultivars of tomato (Solanum lycopersicum),Expand
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Biogeography of Fusarium graminearum species complex and chemotypes: a review
Differences in the geographic distribution of distinct trichothecene mycotoxins in wheat and barley were first recorded two decades ago. The different toxicological properties of deoxynivalenolExpand
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