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Unexpected opioid activity in a known class of drug.
Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no dependence potential. Expand
An opioid benzodiazepine
Although the benzodiazepines have been extensively investigated since their discovery about 20 years ago1, only recently have antagonists of the classical actions of benzodiazepines been described2.Expand
The κ opioid receptor and food intake
Abstract Many studies have suggested a role of opioid receptors in the modulation of food intake. Several distinct classes of opioid receptors have been postulated. In an attempt to establish whichExpand
The effect of the opioid-benzodiazepine, tifluadom, on ingestive behaviors.
Tifluadom's effect on feeding is more potent than that of morphine or ketocyclazocine and equivalent to that of butorphanol and these data provide further support for the concept that kappa opiate receptors represent an important component of the natural feeding drive. Expand
Effects of the opioid benzodiazepine tifluadom and its optical isomers on spontaneous locomotor activity of mice.
The effective antagonisms to the locomotor stimulatory phase of this compound and its enantiomers by Ro 15-1788 points to some interaction with the benzodiazepine/GABA-receptor complex. Expand
The kappa opioid receptor and food intake.
These studies provided further evidence for a role for the kappa opioid receptor in feeding and suggested that more than one subpopulation of opioid receptors is involved in feeding modulation, and showed that the effect on food intake is stereospecific. Expand
1,4-Benzodiazepines and 1,5-benzodiazocines. XI: Synthesis and biological activity
Abstract The synthesis of a new class of anellated 1,4-benzodiazepines with anti-psychotic activity is exemplified by preparation ofExpand