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Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1
TLDR
This new property of KG-1 may allow it to serve as an useful tool for studies of OGG1, oxidative DNA damage and the cytotoxic action of 8ohdG probably due to its incorporation into cellular DNA.
Real-time determination of picomolar free Cu(II) in seawater using a fluorescence-based fiber optic biosensor.
TLDR
Real-time, in situ determination of free copper ion at picomolar levels in seawater using a fluorescence-based fiber optic biosensor is reported, at least comparable to cathodic ligand exchange/adsorptive cathodic stripping voltammetry.
DNA binding, oxidative DNA cleavage, cytotoxicity, and apoptosis-inducing activity of copper(II) complexes with 1,4-tpbd (N,N,N',N'-tetrakis(2-yridylmethyl)benzene-1,4-diamine) ligand.
TLDR
Three new binuclear copper(II) complexes synthesized and structurally characterized by X-ray crystallography have the potential to act as effective metal-based anticancer drugs and display oxidative cleavage of supercoiled DNA in the presence of external agents.
Zinc biosensing with multiphoton excitation using carbonic anhydrase and improved fluorophores.
TLDR
The synthesis and properties of two new probes, Dapoxyl sulfonamide and BTCS, are described and their use in zinc biosensing and the increased zinc-dependent anisotropy response anticipated on the basis of photoselection is described.
Fluorometric determination of the activity of alkaline phosphatase based on the competitive binding of gold nanoparticles and pyrophosphate to CePO4:Tb nanorods
TLDR
A fluorometric method based on the competitive binding of AuNPs and pyrophosphate (PPi) to CePO4:Tb and the hydrolysis of PPi by ALP may find application in the diagnosis of ALP- related diseases, in screening for inhibitors, and in studies on ALP-related functions in biological systems.
Microcalorimetric Investigations of K+- and Mg2+-Induced Polymerization of Actin at Temperatures from 293.15 K to 310.15 K
Microcalorimetric measurements of the polymerization of actin in the presence of 100 mM KCl and 2 mM MgCl2were carried out with a Calvet MS-80 microcalorimeter at temperatures from 293.15 to 310.15
Lanthanide Coordination Polymer Nanoparticles as an Excellent Artificial Peroxidase for Hydrogen Peroxide Detection.
TLDR
This work synthesized novel cerium coordination polymer nanoparticles ATP-Ce-Tris CPNs in a simple and quick way using ATP molecules as the biocompatible ligands to Ce(3+) ions in tris(hydroxymethyl)aminomethane hydrochloric (Tris-HCl) solution to selectively and sensitively detect H2O2.
A luminescent lanthanide coordination polymer based on energy transfer from metal to metal for hydrogen peroxide detection.
TLDR
A bimetal lanthanide coordination polymer nanoparticle with good biocompatibility was synthesized in Tris-HCl buffer using adenosine triphosphate (ATP) molecules as the bridge ligands and exhibit the characteristic green emission of Tb3+.
Lanthanide Phosphate Nanoparticle-Based One-Step Optical Discrimination of Alkaline Phosphatase Activity
Utilizing the dramatic fluorescence difference between the P2O7:Ce,Tb and PO4:Ce,Tb nanoparticles, we proposed the one-step optical strategy for fast, sensitive identification of alkaline phosphata...
Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo
TLDR
The effects of ethaselen and cisplatin combination therapy showed significantly reduced tumor size and no obvious toxic damage, which will be significant in the development of novel anti-tumoral therapeutic strategies directed to non-small cell lung cancer (NSCLC).
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