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Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice
Although glycine is a major inhibitory transmitter in the mammalian CNS, the role of glycinergic neurons in defined neuronal circuits remains ill defined. This is due in part to difficulties inExpand
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GlyR α3: An Essential Target for Spinal PGE2-Mediated Inflammatory Pain Sensitization
Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2-induced receptorExpand
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Reversal of pathological pain through specific spinal GABAA receptor subtypes
Inflammatory diseases and neuropathic insults are frequently accompanied by severe and debilitating pain, which can become chronic and often unresponsive to conventional analgesic treatment. A lossExpand
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Synaptic Integration in Tuft Dendrites of Layer 5 Pyramidal Neurons : A New Unifying Principle
www.sciencemag.org (this information is current as of November 18, 2009 ): The following resources related to this article are available online atExpand
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The AMPA Receptor Subunits GluR-A and GluR-B Reciprocally Modulate Spinal Synaptic Plasticity and Inflammatory Pain
Ca(2+)-permeable AMPA receptors are densely expressed in the spinal dorsal horn, but their functional significance in pain processing is not understood. By disrupting the genes encoding GluR-A orExpand
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Phenotype of V2‐derived interneurons and their relationship to the axon guidance molecule EphA4 in the developing mouse spinal cord
The ventral spinal cord consists of interneuron groups arising from distinct, genetically defined, progenitor domains along the dorsoventral axis. Many of these interneuron groups settle in theExpand
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Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn
Excitatory and inhibitory interneurons of the spinal dorsal horn are critically involved in normal sensory processing and in the generation of pathological pain, but their physiological properties,Expand
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Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
Blockade of prostaglandin (PG) production by COX inhibitors is the treatment of choice for inflammatory pain but is also prone to severe side effects. Identification of signaling elements downstreamExpand
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Glycinergic Projection Neurons of the Cerebellum
The cerebellum funnels its entire output through a small number of presumed glutamatergic premotor projection neurons in the deep cerebellar nuclei and GABAergic neurons that feed back to theExpand
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Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch
Summary The gate control theory of pain proposes that inhibitory neurons of the spinal dorsal horn exert critical control over the relay of nociceptive signals to higher brain areas. Here weExpand
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