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What are secondary metabolites?
- H. Zähner
- BiologyFolia Microbiologica
A reconciliation of divergent ideas of the authors' views of evolution and the observable reality of the secondary metabolism is the aim of this lecture.
Metabolic products of microorganisms
Whereas the minimum inhibitory concentrations of the nikkomycins for growth and germination were quite low, polyoxin A displayed no antifungal activity against yeast cells and sporangiospores of the test organism, even when present in high concentrations.
Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings
It is proposed that the N-terminus (–30 to –1) plays a cooperative role during modification reactions and prevents toxicity of the mature epidermin to the producing strain before the antibiotic is cleaved off and secreted.
Gallidermin: a new lanthionine-containing polypeptide antibiotic.
The isolation procedures for gallidermin included adsorption directly from the culture broth, ion-exchange chromatography of the amphiphilic and basic polypeptide followed by desalting, and final purification by reversed-phase HPLC, which involved mainly a combination of automated gas-phase sequencing, thermospray liquid chromatography/mass spectrometry and fast-atom-bombardment mass spectromaetry.
Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032.
A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion…
Isolation and characterization of staphyloferrin A, a compound with siderophore activity from Staphylococcus hyicus DSM 20459.
- J. Meiwes, H. Fiedler, H. Haag, H. Zähner, S. Konetschny-Rapp, G. Jung
- BiologyFEMS microbiology letters
- 15 January 1990
No evidence that staphylococci synthesize catecholor hydroxamate-type siderophores is found, and a highly hydrophilic compound was isolated from low iron culture broth of StAPHylococcus hyicus DSM 20459.
Epidermin: sequencing of a heterodetic tetracyclic 21-peptide amide antibiotic.
- H. Allgaier, G. Jung, R. Werner, U. Schneider, H. Zähner
- Biology, ChemistryEuropean journal of biochemistry
- 1 October 1986
The complex sequence was elucidated via a combination of desulfurization with Raney nickel, enzymatic and acidolytic degradations, gas-phase sequencing, fast-atom bombardment and field-desorption mass spectrometry and NMR spectroscopy.
Staphyloferrin A: a structurally new siderophore from staphylococci.
- S. Konetschny-Rapp, G. Jung, J. Meiwes, H. Zähner
- Chemistry, BiologyEuropean journal of biochemistry
- 1 July 1990
DL-[5-14C]ornithine was incorporated into staphyloferrin A, demonstrating that ornithine is an intermediate in staphylloferrIn A biosynthesis.
Purification and chemical characterization of staphyloferrin B, a hydrophilic siderophore from staphylococci
The siderophore activity of staphyloferrin B was demonstrated by iron transport measurements, and UV/Vis and circular dichroism spectra are consistent with the proposed structure, which could also be confirmed by precursor feeding.
Structure elucidation of yersiniabactin, a siderophore from highly virulent Yersinia strains
From cultures of Yersinia enterocolitica H1852, an iron-complexing and iron-transporting compound named yersiniabactin was isolated. The structure of the siderophore was determined by a variety of…