• Publications
  • Influence
What are secondary metabolites?
  • H. Zähner
  • Chemistry, Medicine
  • Folia Microbiologica
  • 2008
A reconciliation of divergent ideas of the authors' views of evolution and the observable reality of the secondary metabolism is the aim of this lecture. Expand
Metabolic products of microorganisms
Whereas the minimum inhibitory concentrations of the nikkomycins for growth and germination were quite low, polyoxin A displayed no antifungal activity against yeast cells and sporangiospores of the test organism, even when present in high concentrations. Expand
Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings
It is proposed that the N-terminus (–30 to –1) plays a cooperative role during modification reactions and prevents toxicity of the mature epidermin to the producing strain before the antibiotic is cleaved off and secreted. Expand
Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032.
A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusionExpand
Isolation and characterization of staphyloferrin A, a compound with siderophore activity from Staphylococcus hyicus DSM 20459.
No evidence that staphylococci synthesize catecholor hydroxamate-type siderophores is found, and a highly hydrophilic compound was isolated from low iron culture broth of StAPHylococcus hyicus DSM 20459. Expand
Gallidermin: a new lanthionine-containing polypeptide antibiotic.
The isolation procedures for gallidermin included adsorption directly from the culture broth, ion-exchange chromatography of the amphiphilic and basic polypeptide followed by desalting, and final purification by reversed-phase HPLC, which involved mainly a combination of automated gas-phase sequencing, thermospray liquid chromatography/mass spectrometry and fast-atom-bombardment mass spectromaetry. Expand
Staphyloferrin A: a structurally new siderophore from staphylococci.
DL-[5-14C]ornithine was incorporated into staphyloferrin A, demonstrating that ornithine is an intermediate in staphylloferrIn A biosynthesis. Expand
Structure elucidation of yersiniabactin, a siderophore from highly virulent Yersinia strains
From cultures of Yersinia enterocolitica H1852, an iron-complexing and iron-transporting compound named yersiniabactin was isolated. The structure of the siderophore was determined by a variety ofExpand
Isolation and biological characterization of staphyloferrin B, a compound with siderophore activity from staphylococci.
The structure elucidation revealed 2,3-diaminopropionic acid, citrate, ethylenediamine and 2-ketoglutaric acid as structural components of the compound and established staphyloferrin B is a structurally new siderophore of the complexone type. Expand
Germicidin, an autoregulative germination inhibitor of Streptomyces viridochromogenes NRRL B-1551.
Germicidin is the first known autoregulative inhibitor of spore germination in the genus Streptomyces and was isolated from the supernatant of germinated spores, but also from thesupernatants of the submerged culture. Expand