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An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
It is suggested that F'G' loop movement alters the signalling choice between JAK2 and a Src family kinase by regulating TMD realignment, which could explain debilitated ERK but not STAT5 signalling in some GH-resistant dwarfs and suggest pathway-specific cytokine agonists.
The growth hormone (GH) gene is expressed in the lateral hypothalamus: enhancement by GH-releasing hormone and repression by restraint stress.
GH gene expression in the brain was significantly enhanced by GH-releasing hormone administration and was rapidly repressed by exposure to restraint stress in the water, whereas the changes in pituitary GH messenger RNA contents in these circumstances were relatively smaller.
Characterization of structure and expression of the growth hormone receptor gene of the Japanese flounder (Paralichtys olivaceus).
The findings indicate that the flounder GHR gene diverged from those of mammalian and avian GHR genes, especially in the organization of the exons encoding the cytoplasmic domain.
Restraint stress enhances the gene expression of prolactin receptor long form at the choroid plexus.
The results indicated that the restraint stress caused a rapid increase in serum PRL and induced the gene expression for PRL-R(L) in the choroid plexus, suggesting stress-induced and choroidsplexus PRL(L)-mediated transport of serumPRL into the cerebrospinal fluid.
Gene and cDNA structures of flounder insulin-like growth factor-I (IGF-I): multiple mRNA species encode a single short mature IGF-I.
The results suggest that some unknown transcription initiation factors are functioning in the promotion of IGF-I gene expression.
The effects of endotoxin on plasma free amino acid concentrations in rats.
- Y. Asai, G. Bajotto, H. Yoshizato, K. Hamada, T. Higuchi, Y. Shimomura
- BiologyJournal of nutritional science and vitaminology
- 1 December 2008
The results showed that the availability of administered BCAAs to the body tissues during sepsis is higher following parenteral than peroral administration, and the rise in plasma BCAA concentrations after peroral BCAA administration was significantly suppressed by LPS treatment.
A biphasic regulation of receptor mRNA expressions for growth hormone, glucocorticoid and mineralocorticoid in the rat dentate gyrus during acute stress
Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission
- K. Nishii, Natsuki Matsushita, K. Kobayashi
- Biology, PsychologyJournal of Neuroscience Research
- 15 November 1998
It is demonstrated that dopamine neurotransmission is essential for controlling spontaneous and voluntary movement and associative learning during postnatal development through the nigrostriatal and mesocorticolimbic pathways.
Endurance treadmill training in rats alters CRH activity in the hypothalamic paraventricular nucleus at rest and during acute running according to its period.
Tissue-specific regulation of growth hormone receptor and growth hormone binding protein gene expression during pregnancy and lactation in the rat.
It has been reported that the expression of GH-R and GH-BP mRNAs increases in pregnant mouse liver, and it decreases gradually in the mammary.