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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
It is shown that genetic inactivation of AIF renders embryonic stem cells resistant to cell death after serum deprivation, providing genetic evidence for a caspase-independent pathway of programmed cell death that controls early morphogenesis.
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
It is established that NFATc1 represents a potential therapeutic target for bone disease and a mechanism that underlies the essential role of NF ATc1 in bone homeostasis is revealed.
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
It is reported here that mice bearing a disruption in the NF-ATc gene fail to develop normal cardiac valves and septa and die of circulatory failure before day 14.5 of development, indicating that the Ca2+/calcineurin/NF-atc signalling pathway is essential for normal cardiac valve and septum morphogenesis and hence, NF- ATc and its regulatory pathways are candidates for genetic defects underlying congenital human heart disease.
Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases
Major three factors: IL-6, IL-8, and MCP-1 were strongly correlated with each other indicating a common pathway involved in inflammation process in vitreoretinal diseases.