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Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
It is shown that genetic inactivation of AIF renders embryonic stem cells resistant to cell death after serum deprivation, providing genetic evidence for a caspase-independent pathway of programmed cell death that controls early morphogenesis.
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
It is established that NFATc1 represents a potential therapeutic target for bone disease and a mechanism that underlies the essential role of NF ATc1 in bone homeostasis is revealed.
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation.
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
It is reported here that mice bearing a disruption in the NF-ATc gene fail to develop normal cardiac valves and septa and die of circulatory failure before day 14.5 of development, indicating that the Ca2+/calcineurin/NF-atc signalling pathway is essential for normal cardiac valve and septum morphogenesis and hence, NF- ATc and its regulatory pathways are candidates for genetic defects underlying congenital human heart disease.
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.
Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases
Major three factors: IL-6, IL-8, and MCP-1 were strongly correlated with each other indicating a common pathway involved in inflammation process in vitreoretinal diseases.