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ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP
TLDR
It is concluded that ARAP2 is an Arf6GAP that functions downstream of RhoA to regulate focal adhesion dynamics and not mutants lacking ArfGAP or Rho-binding activity.
A kinase-deficient TrkC receptor isoform activates Arf6–Rac1 signaling through the scaffold protein tamalin
TLDR
It is shown that the neurotrophin-3 (NT3) TrkCT1-truncated receptor binds to the scaffold protein tamalin in a ligand-dependent manner and is established as an upstream regulator of Arf6, establishing a new signaling pathway elicited by the kinase-deficient Trk CT1 receptor.
Src-Dependent Phosphorylation of ASAP1 Regulates Podosomes
TLDR
It is concluded that ASAP1 is a critical target of tyrosine kinase signaling involved in the regulation of podosomes and invadopodia and speculate that ASAP 1 may function as a coincidence detector of simultaneous protein association through the ASAP1 SH3 domain and phosphorylation by Src.
A PH Domain in the Arf GTPase-activating Protein (GAP) ARAP1 Binds Phosphatidylinositol 3,4,5-Trisphosphate and Regulates Arf GAP Activity Independently of Recruitment to the Plasma Membranes*
TLDR
A variation on the model for the function of phosphoinositide-binding PH domains is proposed, in which ARAP1 is recruited to membranes independently of PtdIns(3,4,5)P3, the subsequent production of which triggers enzymatic activity.
PTK6 Inhibits Down-regulation of EGF Receptor through Phosphorylation of ARAP1*
TLDR
It is demonstrated that PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells.
Cassette mutagenesis of lysine 130 of human glutamate dehydrogenase. An essential residue in catalysis.
TLDR
The mutant enzymes containing Glu, Gly, Met, Ser, or Tyr at position 130, as well as the wild-type human GDH encoded by the synthetic gene, were efficiently expressed as a soluble protein and are indistinguishable from that isolated from human and bovine tissues.
Ciclopirox protects mitochondria from hydrogen peroxide toxicity
TLDR
Ciclopirox protects SK‐HEP‐1 cells from H2O2 cytotoxicity by inhibiting Δψm decrease and indirectly preventing MPTP opening.
ARAP2 Signals through Arf6 and Rac1 to Control Focal Adhesion Morphology*
TLDR
It is speculated that ARAP2 has additional functions that are effector in nature to promote or stabilize FAs and changes in Arf6 and Rac1 activities are necessary but not sufficient for AR AP2 to promote the growth of FAs.
Importance of Glutamate 279 for the Coenzyme Binding of Human Glutamate Dehydrogenase*
TLDR
The results with photoaffinity labeling and cassette mutagenesis studies suggest that Glu279 plays an important role for efficient binding of NAD+ to human GDH.
Decreased expression of glutamate dehydrogenase by prolonged intake of monosodium glutamate in rat brain
TLDR
It is indicated that the prolonged monosodium glutamate feeding reduces the activity of GDH and subsequently decreases the catabolism of glutamate in rat brain.
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