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Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis
Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for heterodimer formation was investigated byExpand
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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1. Here we describe the crystal and solution structures of a Bcl-2 family member, Bcl-xL (ref. 2). The structuresExpand
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Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
THE pleckstrin homology (PH) domain is a new protein module of around 100 amino acids found in several proteins involved in signal transduction1–5. Although its specific function has yet to beExpand
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Solution structure of the antiapoptotic protein bcl-2
  • A. Petros, A. Medek, +6 authors S. Fesik
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 27 February 2001
The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in solution, the structures were determined byExpand
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FKBP Family Proteins: Immunophilins with Versatile Biological Functions
Immunophilins consist of a family of highly conserved proteins binding with immunosuppressive drugs such as FK506, rapamycin and cyclosporin A. FK506-binding protein (FKBP) is one of two majorExpand
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Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease
Significance Parkinson’s disease (PD) is the most prevalent movement disorder with no available treatments that can stop or slow down the disease progress. Although the orphan nuclear receptor Nurr1Expand
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Mitotic Histone H3 Phosphorylation by Vaccinia-Related Kinase 1 in Mammalian Cells
ABSTRACT Mitotic chromatin condensation is essential for cell division in eukaryotes. Posttranslational modification of the N-terminal tail of histone proteins, particularly by phosphorylation byExpand
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Co-delivery of drugs and DNA from cationic core–shell nanoparticles self-assembled from a biodegradable copolymer
Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited their applications1. Co-delivery of drugsExpand
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Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin
The nuclear immunophilin FKBP25 interacts with chromatin-related proteins and transcription factors and is suggested to interact with nucleic acids. Currently the structural basis of nucleic acidExpand
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Structural characterization of the interaction between a pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate.
The pleckstrin homology (PH) domain is a protein module of approximately 100 amino acids that is found in several proteins involved in signal transduction [for a recent review, see Gibson et al.Expand
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