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EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications.
Lung cancer is the leading cause of cancer-related death. The identification of epidermal growth factor receptor (EGFR) somatic mutations defined a new, molecularly classified subgroup of… Expand
Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer
- H. Yasuda, E. Park, +21 authors D. B. Costa
- Medicine, Biology
- Science Translational Medicine
- 18 December 2013
Crystal structure and detailed analysis of different EGFR mutants explain why some mutations in exon 20 make lung cancers resistant to EGFR inhibitors and others make them more sensitive. A Crystal… Expand
Transformation of carbon dioxide.
4.3. Reaction Mechanism 2373 4.4. Asymmetric Synthesis 2374 4.5. Outlook 2374 5. Alternating Polymerization of Oxiranes and CO2 2374 5.1. Reaction Outlines 2374 5.2. Catalyst 2376 5.3. Asymmetric… Expand
Preclinical Rationale for Use of the Clinically Available Multitargeted Tyrosine Kinase Inhibitor Crizotinib in ROS1-Translocated Lung Cancer
- H. Yasuda, L. L. de Figueiredo-Pontes, S. Kobayashi, D. B. Costa
- Journal of thoracic oncology : official…
- 1 July 2012
Introduction: Most clinically available small-molecule kinase inhibitors are multi-targeted and can inhibit multiple kinases. Our driving hypothesis was that one of these multi-targeted tyrosine… Expand
Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC
- H. Terai, K. Soejima, +11 authors T. Betsuyaku
- Biology, Medicine
- Molecular Cancer Research
- 27 March 2013
Patients with non-small cell lung cancer (NSCLC) that harbors epidermal growth factor receptor (EGFR) mutations initially respond to EGFR-tyrosine kinase inhibitors (TKI) but eventually experience… Expand
A new in-vitro drug sensitivity test (collagen-gel droplet embedded-culture drug sensitivity test) in carcinomas of pancreas and biliary tract: possible clinical utility.
- H. Yasuda, T. Takada, +5 authors N. Toyota
- Journal of hepato-biliary-pancreatic surgery
- 1 November 1998
The collagen-gel droplet embedded-culture drug sensitivity test (CD-DST), a chemosensitivity test, evaluate the efficacy of anticancer drugs and to was used clinically to thus plan rational… Expand
Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.
- H. Yasuda, M. Nagata, +9 authors M. Kasuga
- The Journal of clinical investigation
- 15 November 1998
Local production of immunosuppressive cytokines will be one of the most suitable therapeutic strategies against organ-specific autoimmune diabetes. To establish such a new therapy, we constructed… Expand
Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing.
PURPOSE We sought to determine the mechanisms of downregulation of the airway transcription factor Foxa2 in lung cancer and the expression status of Foxa2 in non-small-cell lung cancer (NSCLC). … Expand
Selective and high yield synthesis of dimethyl carbonate directly from carbon dioxide and methanol
Supercritical carbon dioxide is efficiently converted to dimethyl carbonate (DMC) via the reaction with methanol in the presence of a catalytic amount of dialkyltin oxide or its derivatives. The… Expand
Predictive Physics-Based TCAD Modeling of the Mixed-Mode Degradation Mechanism in SiGe HBTs
- K. A. Moen, P. Chakraborty, U. Raghunathan, J. Cressler, H. Yasuda
- IEEE Transactions on Electron Devices
- 31 August 2012
We study mixed-mode stress degradation in SiGe HBTs using a novel physical TCAD model in which the processes of hot carrier generation within the semiconductor, carrier propagation to the oxide… Expand