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Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer.
MicroRNAs (miRNA) are small noncoding RNA molecules involved in a diversity of cellular functions. Although it has been reported that global suppression of the miRNA biogenesis pathway leads to… Expand
Genetic Variations in MicroRNA-Related Genes Are Novel Susceptibility Loci for Esophageal Cancer Risk
MicroRNAs (miRNA) can act as oncogenes or tumor suppressors and modulate the expression of approximately one third of all human genes. To test the hypothesis that adverse alleles in miRNA-related… Expand
Single Nucleotide Polymorphisms of microRNA Machinery Genes Modify the Risk of Renal Cell Carcinoma
Purpose: MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of basic cellular functions through posttranscriptional regulations on their target… Expand
Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.
- M. A. Hildebrandt, H. Yang, +5 authors X. Wu
- Journal of clinical oncology : official journal…
- 20 February 2009
PURPOSE The phosphoinositide-3-kinase (PI3K), phosphatase and tensin homolog (PTEN), v-akt murine thymoma viral oncogene homolog (AKT), and mammalian target of rapamycin (mTOR) signaling pathway has… Expand
MicroRNA Expression Signatures in Barrett's Esophagus and Esophageal Adenocarcinoma
Purpose: Esophageal adenocarcinoma is a highly aggressive malignancy that frequently develops from Barrett's esophagus, a premalignant pathologic change occurring in the lower end of the esophagus.… Expand
Genetic Variants in Cell Cycle Control Pathway Confer Susceptibility to Lung Cancer
Purpose: To test the hypothesis that common sequence variants of cell cycle control genes may affect lung cancer predisposition. Experimental Design: We explored lung cancer risk associations of 11… Expand
Genetic variation in MicroRNA genes and risk of oral premalignant lesions
MicroRNAs (miRNAs) have been reported to play a key role in oncogenesis and, recently, studies have examined the role miRNAs might play in the risk of premalignant lesions. To our knowledge, no study… Expand
Genetic Variations in the Sonic Hedgehog Pathway Affect Clinical Outcomes in Non–Muscle-Invasive Bladder Cancer
Sonic hedgehog (Shh) pathway genetic variations may affect bladder cancer risk and clinical outcomes. Therefore, we genotyped 177 single-nucleotide polymorphisms (SNP) in 11 Shh pathway genes in a… Expand
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
- N. Rothman, M. García-Closas, +107 authors S. Chanock
- Medicine, Biology
- Nature Genetics
- 17 September 2010
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five… Expand
Modulation of DNA damage/DNA repair capacity by XPC polymorphisms.
XPC, a key protein in the nucleotide excision repair (NER) pathway, recognizes damaged DNA and initiates NER. Genetic variations in the XPC gene might be associated with altered DNA repair capacities… Expand