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MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN.
MicroRNAs (miRNA) represent a novel class of genes that function as negative regulators of gene expression. Recently, miRNAs have been implicated in several cancers. However, aberrant miRNAExpand
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2
Alternative hosts and model animals The severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) pandemic may have originated in bats, but how it made its way into humans is unknown. Because ofExpand
H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet
H7N9 Adaptation Puzzling and alarming reports of an outbreak in early 2013 of human infections by a low-pathogenicity avian influenza virus has rocked the poultry industry in central eastern ChinaExpand
A Naturally Occurring Deletion in Its NS Gene Contributes to the Attenuation of an H5N1 Swine Influenza Virus in Chickens
ABSTRACT In 2001 and 2003, we isolated two H5N1 viruses, A/swine/Fujian/1/01 (SW/FJ/01) and A/swine/Fujian/1/03 (SW/FJ/03), from pigs in Fujian Province, southern China. Genetically, these twoExpand
Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site
  • X. Zhu, H. Yang, +9 authors I. Wilson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 24 September 2012
Recently, we reported a unique influenza A virus subtype H17N10 from little yellow-shouldered bats. Its neuraminidase (NA) gene encodes a protein that appears to be highly divergent from all knownExpand
Rapid Evolution of H7N9 Highly Pathogenic Viruses that Emerged in China in 2017.
H7N9 low pathogenic influenza viruses emerged in China in 2013 and mutated to highly pathogenic strains in 2017, resulting in human infections and disease in chickens. To control spread, a bivalentExpand
Prevalence, genetics, and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza viruses
  • H. Yang, Y. Chen, +13 authors H. Chen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 28 December 2015
Significance Animal influenza viruses continue to challenge human public health; surveillance of these viruses and evaluation of their pandemic potential are important for future influenza pandemicExpand
Human Infection from Avian-like Influenza A (H1N1) Viruses in Pigs, China
In investigating influenza in an immunodeficient child in China, in December 2010, we found that the influenza virus showed high sequence identity to that of swine. Serologic evidence indicated thatExpand
Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19, which was first reported in Wuhan, China in December, 2019. Despite the tremendous efforts toExpand
Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth.
Dysregulation of the sterol regulatory element-binding transcription factors sterol regulatory element-binding protein (SREBP) and SREBF activates de novo lipogenesis to high levels in cancer cells,Expand