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Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia.
Pantothenate kinase-associated neurodegeneration (PKAN, formerly known as Hallervorden-Spatz syndrome) is a rare but devastating neurodegenerative disorder, resulting from an inherited defect inExpand
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The Taste of Monosodium Glutamate: Membrane Receptors in Taste Buds
Receptor proteins for photoreception have been studied for several decades. More recently, putative receptors for olfaction have been isolated and characterized. In contrast, no receptors for tasteExpand
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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.
von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germ line mutation of the von Hippel-Lindau tumor suppressor gene (VHL). Tumors observed in this disorder include retinal andExpand
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Retinal TrkB receptors regulate neural development in the inner, but not outer, retina
BDNF signaling through its TrkB receptor plays a pivotal role in activity-dependent refinement of synaptic connectivity of retinal ganglion cells. Additionally, studies using TrkB knockout mice haveExpand
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Vesicular Glutamate Transporter 1 Is Required for Photoreceptor Synaptic Signaling But Not For Intrinsic Visual Functions
Glutamatergic neurotransmission requires vesicular glutamate transporters (VGLUTs) to sequester glutamate into synaptic vesicles. Generally, VGLUT1 and VGLUT2 isoforms show complementary expressionExpand
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Synaptic protein expression by regenerating adult photoreceptors
Regeneration of functionally normal synapses is required for functional recovery after degenerative central nervous system insults and requires proper expression and targeting of presynaptic proteinsExpand
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Antitumor and immunomodulatory activity of polysaccharides from the root of Limonium sinense Kuntze.
Limonium sinense (Girard) Kuntze is a traditional Chinese folk medicine used for the treatment of fever, hemorrhage, hepatitis and other disorders. The study focused on the antitumor andExpand
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Scotopic Visual Signaling in the Mouse Retina Is Modulated by High-Affinity Plasma Membrane Calcium Extrusion
Transmission of visual signals at the first retinal synapse is associated with changes in calcium concentration in photoreceptors and bipolar cells. We investigated how loss of plasma membrane Ca2+Expand
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Vesicle‐associated membrane protein isoforms in the tiger salamander retina
Vesicle associated membrane protein (VAMP; also known as synaptobrevin) is a key component of the core complex needed for docking and fusion of synaptic vesicles with the presynaptic plasma membrane.Expand
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Sustained delivery of NT‐3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations
Several neurotrophic factors (NTFs) are effective in protecting retinal photoreceptor cells from the damaging effects of constant light and slowing the rate of inherited photoreceptor degenerations.Expand
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