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Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.
Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is currently being used clinically for the treatment of alcoholism.Expand
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Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.
Interest in the use of traditional medicines for cancer prevention and treatment is increasing. In vitro, in vivo, and clinical studies suggest the potential use of proteasome inhibitors as novelExpand
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The Tumor Proteasome Is a Primary Target for the Natural Anticancer Compound Withaferin A Isolated from “Indian Winter Cherry”
Withaferin A (WA) is a steroidal lactone purified from medicinal plant “Indian Winter Cherry” that is widely researched for its variety of properties, including antitumor effects. However, theExpand
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Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo
Dysregulation of the ubiquitin‐proteasome pathway plays an essential role in tumor growth and development. Shikonin, a natural naphthoquinone isolated from the traditional Chinese medicine Zi CaoExpand
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Broad targeting of resistance to apoptosis in cancer
Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks to eliminateExpand
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EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment.
Cancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such asExpand
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Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.
The proteasome is a multicatalytic protease complex that degrades most endogenous proteins including misfolded or damaged proteins to ensure normal cellular function. The ubiquitin-proteasomeExpand
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S-Nitrosylation Positively Regulates Ascorbate Peroxidase Activity during Plant Stress Responses1
Nitric oxide positively regulates a key Arabidopsis peroxidase through S-nitrosylation and enhances resistance to oxidative stresses. Nitric oxide (NO) and reactive oxygen species (ROS) are twoExpand
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Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and
Tumor growth and metastasis depend on angiogenesis that requires the cofactor copper. Consistently, high levels of copper have been found in many types of human cancers, including prostate, breast,Expand
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Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells
Pristimerin is a natural product derived from the Celastraceae and Hippocrateaceae families that were used as folk medicines for antiinflammation in ancient times. Although it has been shown thatExpand
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