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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
TLDR
2-HG is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases, leading to genome-wide histone and DNA methylation alterations. Expand
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
TLDR
Tet3-mediated DNA hydroxylation is involved in epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprograming during animal cloning. Expand
Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition
TLDR
The comparative analysis demonstrated that particle composition probably played a primary role in the cytotoxic effects of different nanoparticles, however, the potential genotoxicity might be mostly attributed to particle shape. Expand
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
TLDR
This study suggests that tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple α-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation. Expand
Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.
TLDR
It is reported that common and tumor-specific splicing aberrations are induced by SF3B1 mutations and establish aberrant 3' ss selection as the most frequent splicing defect. Expand
Molecular Basis of Spectral Tuning in the Red- and Green-Sensitive (M/LWS) Pigments in Vertebrates
TLDR
It is shown that the molecular basis of the spectral tuning of contemporary visual pigments can be illuminated only by mutagenesis analyses using ancestral pigments, and the “five-sites” rule is derived that explains the absorption spectra of red and green (M/LWS) pigments that range from 510 to 560 nm. Expand
IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives
TLDR
Abnormal histone and DNA methylation are emerging as a common feature of tumors with IDH1 and IDH2 mutations and may cause altered stem cell differentiation and eventual tumorigenesis. Expand
cGAS is essential for cellular senescence
TLDR
It is shown that cGAS mediates cellular senescence and retards immortalization, a cytosolic DNA sensor that activates innate immunity, which is distinct from, and complementary to, the role ofcGAS in activating antitumor immunity. Expand
Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase
TLDR
Findings indicated that miR-155 is an essential regulator of eNOS expression and endothelium-dependent vasorelaxation and may be a new therapeutic approach to improve endothelial dysfunction during the development of cardiovascular diseases. Expand
The Role of a Novel p97/Valosin-containing Protein-interacting Motif of gp78 in Endoplasmic Reticulum-associated Degradation*
TLDR
It is suggested that gp78 might act in a UFD1-independent degradation pathway for misfolded ER proteins, which operates in parallel with the previously established p97/VCP-Ufd1-Npl4-mediated mechanism. Expand
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