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Morphological transformation of microglia in vitro
Isolated microglia underwent in vitro morphological transformation to ameboid, rod-shaped and ramified forms in response to several cytokines, factors from astrocytes, or factors which affectExpand
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FK1706, a novel non-immunosuppressive immunophilin: neurotrophic activity and mechanism of action.
Immunophilin ligands are neuroregenerative agents, characterized by binding to FK506 binding proteins (FKBPs), which stimulate recovery of neurons in a variety of injury paradigms. Here we report theExpand
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Regulation of leaf organ size by the Arabidopsis RPT2a 19S proteasome subunit.
The ubiquitin/26S proteasome pathway plays a central role in the degradation of short-lived regulatory proteins, to control many cellular events. To further understand this pathway, we focused on theExpand
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Pharmacological Characterization of a Novel, Potent Adenosine A1 and A2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in Models of
Central adenosine A2A receptor is a promising target for drugs to treat Parkinson's disease (PD), and the central blockade of adenosine A1 receptor improves cognitive function. In the present study,Expand
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  • Open Access
Effects of colony stimulating factors on isolated microglia in vitro
Effects of colony stimulating factors (CSF), known regulators for cells in monocytic lineage, on isolated microglia were examined. Interleukin-3 (IL-3) induced only morphological changes inExpand
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Stable Transfection of GM1 Synthase Gene into GM1-Deficient NG108-15 Cells, CR-72 Cells, Rescues the Responsiveness of TRK-Neurotrophin Receptor to Its Ligand, NGF
Previous studies from this laboratory and others have suggested the evidences that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factorExpand
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Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C
Microglia were isolated from primary mixed brain cell culture of normal newborn mice and then cultivated. They were able to be maintained in vitro for 1-2 months, but incorporated littleExpand
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Serotonin-induced acute desensitization of serotonin2 receptors in human platelets via a mechanism involving protein kinase C.
Serotonin (5-HT)-induced changes in the levels of intracellular Ca++ were analyzed in human platelets, using the Ca+(+)-sensitive dye 1-(2-(5'-carboxyoxazol-2'-yl)-6-aminobenzofuran-5-oxy)-2-(2'Expand
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FK1706, a novel non-immunosuppressive immunophilin ligand, modifies the course of painful diabetic neuropathy
FK1706, a derivative of FK506, is a non-immunosuppressive immunophilin ligand with significant neurotrophic activity mediated via FKBP-52 and the RAS/RAF/MAPK signaling pathway. Here, we tested theExpand
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Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice.
In peripheral nociceptive flexor test, SA4503, (+)-pentazocine, and (+)-3-(hydroxyphenyl)-N-(1-propyl)piperidine, representative sigma-receptor agonists, elicited dose-dependent flexor responses.Expand
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