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NMR conformational analysis of proadrenomedullin N‐terminal 20 peptide, a proangiogenic factor involved in tumor growth
The preferred conformation of Proadrenomedullin N‐Terminal 20 Peptide (PAMP; ARLDVASEFRKKWNKWALSR‐amide) has been determined using 1H and 13C two‐dimensional nuclear magnetic resonance (NMR) spectroscopy and molecular modeling, and it is postulated that the polar charged residues Arg2, Lys12, and Arg20 are responsible for the initial interaction of the peptide with the micelle. Expand
An nmr conformational analysis of a synthetic peptide Cn2(1-15)NH2-S-S-acetyl-Cn2(52-66)NH2 from the New World Centruroides noxius 2 (Cn2) scorpion toxin: comparison of the structure with those of…
- H. Yamamoto, J. Sejbal, E. York, J. Stewart, L. Possani, G. Kotovych
- Chemistry, Medicine
- 5 April 1999
The conformation of this region evidently plays an important role in receptor recognition and in binding to the neutralizing monoclonal antibody BCF2 raised against the intact toxin. Expand
NMR and CD conformational studies of bradykinin and its agonists and antagonists: application to receptor binding.
- G. Kotovych, J. Cann, J. Stewart, H. Yamamoto
- Biochemistry and cell biology = Biochimie et…
These techniques for the determination of peptide conformation are reviewed and applied to the study of bradykinin and its antagonists and the biologically active conformations are deduced. Expand
Syntheses and conformational studies of poly‐β,N‐alkyl L‐asparagines
From the results obtained, poly‐β‐N‐benzyl L‐asparagine was found to be a random coil structure in dichloroacetic acid and the optical rotatory dispersion curves gradually changed into the left‐handed α‐helix structure when chloroform was added to the solution. Expand
Synthesis and conformational study of poly(Nϵ‐benzyl‐L‐lysine) and its benzyloxycarbonyl derivative
The solvent‐and pH‐induced conformational changes are examined in order to investigate the influence of benzyl group and the breakdown of the helical conformation is found to occur at 8% dichloroacetic acid in chloroform‐dichloroACetic acid mixture. Expand
The synthesis of poly-L-arginine hydrobromide and copolymers of L-arginine and other amino acids.
- T. Hayakawa, Y. Kondo, H. Yamamoto, Y. Murakami
- Chemistry, Medicine
- Bulletin of the Chemical Society of Japan
- 1 February 1969
Several copolymers containing L-arginine residue were also prepared by the copolymerization of the above NCA and the NCAs of other amino acids, such as γ-benzyl-L-glutamate, L-alanine, and Ne-carbobenzyloxy- L-lysine. Expand
Syntheses and conformational studies of poly(N-epsilon-methyl-L-lysine), poly(N-delta-methyl-L-ornithine), poly(N-delta-ethyl-L-ornithine), and their carbobenzoxy derivatives.
Syntheses of poly[beta-(l)-menthyl D- and L-aspartates] and their secondary structures.
An NMR conformational analysis of cyclic bradykinin mimics. Evidence for a beta-turn.
- M. Miskolzie, H. Yamamoto, E. York, J. Stewart, G. Kotovych
- Journal of biomolecular structure & dynamics
A detailed NMR study is carried out in acetonitrile/water solutions on three novel cyclic bradykinin antagonist analogues, BKM-824, BKM-870, and BKM-872, to examine their solution structures, and to… Expand