• Publications
  • Influence
Mechanism of Arachidonic Acid Liberation During Ischemia in Gerbil Cerebral Cortex
Abstract: Once brain ischemia was induced in the gerbil cerebral fronto‐parietal cortex, serial changes occurred in energy metabolites and various lipids. The amounts of inosi‐tol‐containingExpand
  • 273
  • 12
Dephosphorylation of Microtubule‐Associated Protein 2, τ Factor, and Tubulin by Calcineurin
Abstract: Calcineurin dephosphorylated microtubule‐associated protein 2 (MAP2) and τ factor phosphorylated by cyclic AMP‐dependent and Ca2+, calmodulin‐dependent protein kinases from the brain.Expand
  • 166
  • 7
Interaction of NE-dlg/SAP102, a Neuronal and Endocrine Tissue-specific Membrane-associated Guanylate Kinase Protein, with Calmodulin and PSD-95/SAP90
NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase family protein, is known to bind to C-terminal ends ofN-methyl-d-aspartate receptor 2B (NR2B) through itsExpand
  • 77
  • 7
Staurosporine: An Effective Inhibitor for Ca2+/Calmodulin‐Dependent Protein Kinase II
Abstract: We investigated the effect of staurosporine on Ca2+/calmodulin‐dependent protein kinase II (CaM kinase II) purified from rat brain. (a) Staurosporine (10–100 nM) inhibited the activity ofExpand
  • 152
  • 6
Interaction of the Extracellular Domain of the Epidermal Growth Factor Receptor with Gangliosides*
Ganglioside GM3 inhibits epidermal growth factor (EGF)-dependent cell proliferation in a variety of cell lines. Both in vitro and in vivo, this glycosphingolipid inhibits the kinase activity of theExpand
  • 149
  • 6
  • PDF
Differential roles of Ca(2+)/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation.
The roles of Ca(2+)/calmodulin-dependent protein kinase II (CaM kinase II) and mitogen-activated protein kinase (MAPK) in long-term potentiation (LTP) were investigated in the CA1 area of hippocampalExpand
  • 49
  • 6
  • PDF
Glutamine Synthetase of the Human Brain: Purification and Characterization
Glutamine synthetase (GS) isolated from human brain formed a single band on sodium dodecyl sulfate‐poly‐acrylamide gel with a molecular weight of 44,000. The enzyme had a specific activity of 179.2Expand
  • 44
  • 4
Robust NADH-regenerator: improved α-haloketone-resistant formate dehydrogenase
Formate dehydrogenases (FDH) are useful for the regeneration of NADH, which is required for asymmetric reduction by several dehydrogenases and reductases. FDHs have relatively low activity and areExpand
  • 43
  • 4
Ischemia‐Induced Loss of Brain Calcium/Calmodulin‐Dependent Protein Kinase II
Abstract: Forebrain ischemia in gerbils, produced by brief bilateral carotid occlusion, induced the dramatic loss of Ca2+/ calmodulin‐dependent protein kinase II (CaM‐kinase II) as determined by bothExpand
  • 68
  • 3
Purification and Characterization of a Ca2+‐ and Calmodulin‐Dependent Protein Kinase from Rat Brain
Abstract: A Ca2+‐ and calmodulin‐dependent protein kinase was purified from rat brain cytosol fraction to apparent homogeneity at approximately 800‐fold and with a 5% yield. The purified enzyme had aExpand
  • 197
  • 2