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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin
Glycogen synthase kinase‐3 (GSK‐3) mediates epidermal growth factor, insulin and Wnt signals to various downstream events such as glycogen metabolism, gene expression, proliferation andExpand
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Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.
beta-catenin-mediated Wnt signaling is critical in animal development and tumor progression. The single-span transmembrane Wnt receptor, low-density lipoprotein receptor-related protein 6 (LRP6),Expand
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Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling.
Wnt-5a is a representative ligand that activates a beta-catenin-independent pathway in Wnt signalling. In the present paper, the roles of the post-translational modifications in the actions of Wnt-5aExpand
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Selective activation mechanisms of Wnt signaling pathways.
Wnts comprise a large family of secreted, hydrophobic glycoproteins that control a variety of developmental and adult processes in all metazoan organisms, including cellular proliferation,Expand
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Wnt5a regulates distinct signalling pathways by binding to Frizzled2
Wnt5a regulates multiple intracellular signalling cascades, but how Wnt5a determines the specificity of these pathways is not well understood. This study examined whether the internalization of WntExpand
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New insights into the mechanism of Wnt signaling pathway activation.
Wnts compromise a large family of secreted, hydrophobic glycoproteins that control a variety of developmental and adult processes in all metazoan organisms. Recent advances in the Wnt-signal studiesExpand
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Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.
Wnt and Dickkopf (Dkk) regulate the stabilization of beta-catenin antagonistically in the Wnt signaling pathway; however, the molecular mechanism is not clear. In this study, we found that Wnt3a actsExpand
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Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.
Sumoylation is involved in mediating protein-protein interactions, subcellular compartmentalization and protein stability. Our analysis of various Wnt signaling molecules revealed that one of them,Expand
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Regulation of Wnt signaling by protein-protein interaction and post-translational modifications
The Wnt signaling pathway is conserved in various species from worms to mammals, and plays important roles in cellular proliferation, differentiation, and migration. Wnt stabilizes cytoplasmicExpand
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Mechanism of zeolite synthesis from coal fly ash by alkali hydrothermal reaction
Abstract To clarify the mechanism of zeolite synthesis from coal fly ash, the hydrothermal reaction was carried out in various alkali solutions. Zeolite was synthesized in an 800-cm 3 autoclave underExpand
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