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Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.
TLDR
The results of coexpression of wild-type TERT and TERT with aplastic anemia-associated mutations in a telomerase-deficient cell line suggested that haploinsufficiency was the mechanism of telomere shortening due to TERT mutations.
Mobile Genetic Element SCCmec-encoded psm-mec RNA Suppresses Translation of agrA and Attenuates MRSA Virulence
TLDR
It is reported that psm-mec RNA inhibits translation of the agrA gene encoding a positive transcription factor for the PSMα gene via specific binding to agRA mRNA, which suppresses MRSA virulence via inhibition of agr a translation and the absence of psm -mec function in CA-MRSA causes its high virulence property.
Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome.
TLDR
The results suggest that cryptic DKC, at least secondary to mutations in the TERC gene, is an improbable diagnosis in patients with otherwise typical AA, PNH, and MDS.
Activated K-Ras protein accelerates human MLL/AF4-induced leukemo-lymphomogenicity in a transgenic mouse model
TLDR
Activated K-Ras protein accelerates human MLL/AF4-induced leukemo-lymphomogenicity in a transgenic mouse model and shows anti-cancer properties.
Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.
TLDR
This study clearly shows that FLT3-ITD AML requires additional driver genetic alterations in addition to FLT2-ITd alone, and DNMT3A mutations are the most stable mutations.
Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil
TLDR
MTX-containing prophylaxis is preferred in UCBT for standard-risk disease, whereas MMF-containing Prophylaxes is preferred for advanced- risk disease.
Renal thrombotic microangiopathy associated with chronic graft‐versus‐host disease after allogeneic hematopoietic stem cell transplantation
TLDR
The kidney is a potential target of chronic GVHD that may induce the development of HSCT‐associated renal TMA, and some cases are associated with chronic humoral GV HD.
Efficiency of high-dose cytarabine added to CY/TBI in cord blood transplantation for myeloid malignancy.
TLDR
This study is the first to show the superiority of HDCA/CY/ TBI to CY/TBI in CBT for AML/MDS, and a large-scale prospective study is warranted to establish new conditioning regimens including HDCA administration.
Abnormality of c-kit oncoprotein in certain patients with chronic myelogenous leukemia – potential clinical significance
TLDR
Analysis of alterations of the c-kit gene and in vitro functional analyses raise the possibility that the KIT abnormalities influence the white blood cell counts and survival of CML patients.
A Novel Gene, fudoh, in the SCCmec Region Suppresses the Colony Spreading Ability and Virulence of Staphylococcus aureus
TLDR
It is suggested that fudoh in the SCCmec type-II region suppresses colony spreading and exotoxin production, and is involved in S. aureus pathogenesis.
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