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Inhibitory Actions of Endothelin-1 on Pain Processing
TLDR
Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission and the manner by which ET-1 exerts this action was investigated, suggesting that the antinociceptive effect involved a descending pain inhibitory system.
View on Wolters Kluwer
Statuses of food-derived glutathione in intestine, blood, and liver of rat
TLDR
The findings indicate that food-derived glutathione is directly absorbed in its electrochemically reduced form in the intestine, is then transported in the blood in bound forms, and is finally deposited into the liver in reduced form, upon entering the bloodstream.
View on Springer
Comparison of retinal nerve-fiber layer in high- and normal-tension glaucoma
TLDR
The hypothesis that there may be different mechanisms of damage in glaucoma is supported as subjects with NTG showed more localized RNFL loss than diffuse loss as compared with HTG patients.
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Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors
View on Elsevier
The group at C2 of N-ethylnicotinamide determines the vasodilator potencies and mechanisms of action of nicorandil and its congeners in canine coronary arteries
TLDR
The results indicate that the group at C2 of the parent structure of nicorandil and its congeners, i.e., N-ethylnicotinamide determines not only the vasodilator potency but the vasODilator mechanism of action of the compound.
View on Springer
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries
TLDR
In canine large epicardial coronary arteries cromakalim produced relaxation by the mechanism antagonized by glibenclamide, probably opening ATP-sensitive potassium channels, pinacidil and nicorandil did so by the mechanisms shared with cromkalim and by one not antagonizedby glibanclamide as well, and Nicorandils did so exclusively by the mode of action as a nitrate.
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Nicorandil as a nitrate, and cromakalim as a potassium channel opener, dilate isolated porcine large coronary arteries in an agonist-nonselective manner
TLDR
The results indicate that the vasorelaxant actions of nicorandil and cromakalim in the porcine large coronary artery are agonist nonselective and that nicor andil exerts such an action entirely as a nitrate, whereas cromkalim does so entirely asA potassium channel opener.
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Diffuse nerve fiber layer loss in normal tension glaucoma
TLDR
The result suggests that, even in NTG, IOP may be an important factor causing optic nerve damage, and that retinal nerve fiber layer loss in the RNFL area corresponded to the spared visual hemifield as compared to those with the maximum IOP<19 mmHg.
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533 – Generation of Novel Pik3Ca-Induced Gastric Cancer Mouse Model
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Immunological liver injury model in mice.
TLDR
The results suggest that the experimental liver injury model in DBA/2 mice is useful for immunopharmacological studies of liver diseases.
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