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Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*
TLDR
OCTN2 is a physiologically important, high affinity sodium-carnitine cotransporter in humans, and the functional characteristics of OCTN2 coincide with those reported for plasma membrane carnitine transport. Expand
ABC transporter AtABCG25 is involved in abscisic acid transport and responses
TLDR
Results strongly suggest that AtABCG25 is an exporter of ABA and is involved in the intercellular ABA signaling pathway, and sheds light on the active control of multicellular ABA responses to environmental stresses among plant cells. Expand
Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1
TLDR
Although its subcellular localization and detailed functional characteristics are not clear at present, OCTN1 appears to be a novel proton antiporter that functions for active secretion of cationic compounds across the renal epithelial brush‐border membrane and may play a role in the renal excretion of xenobiotics and their metabolites. Expand
Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
TLDR
These mutations provide the first evidence that loss of OCTN2 function causes primary systemic carnitine deficiency, an autosomal recessive disorder characterized by progressive cardiomyopathy, skeletal myopathy, hypoglycaemia and hyperammonaemia. Expand
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
TLDR
Functional characteristics of OCTN1 were investigated and it was functionally demonstrated to be a multispecific and pH-dependent organic cation transporter, which presumably functions as a proton/organic cation antiporter at the renal apical membrane and other tissues. Expand
Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12.
TLDR
By searching cDNA libraries from various human tissues, alternative splicing variants of ABCC11 and ABCC12 genes at significantly high frequencies are identified and may represent diverse biological functions of these ABC transporter genes. Expand
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
TLDR
The results suggest that the carnitine deficiency-related toxicological effects by long-term treatment with such drugs might be ascribed to a functional alteration of hOCTN2-mediated carnitines transport. Expand
p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1.
TLDR
It is shown that human NPT1, which is present in renal apical membrane, mediates the transport of PAH, and the K(m) value for PAH uptake was 2.66 mM and the uptake was chloride ion sensitive. Expand
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.
TLDR
Overexpression of human kidney-specific organic anion transporter SLCO4C1 in rat kidney reduced hypertension, cardiomegaly, and inflammation and increased the clearance of asymmetric dimethylarginine and trans-aconitate in renal failure, suggesting that drugs that upregulate SLCC1 may have therapeutic potential for patients with CKD. Expand
Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers
TLDR
Valsartan, olmesartan and pratosartan could inhibit the OAT3-mediated uric acid secretion in clinical situations and losartan may inhibit ATP-dependent uric Acid secretion by MRP4, which may explain partially the alteration of serum Uric acid level by ARBs. Expand
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