• Publications
  • Influence
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants of Alzheimer diseaseExpand
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TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces Apoptosis*
The members of the tumor necrosis factor (TNF) family play pivotal roles in the regulation of the immune system. Here we describe a new ligand in this family, designated TWEAK. The mouse and humanExpand
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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)*
  • Y. Atagi, C. Liu, +11 authors G. Bu
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 15 September 2015
Background: TREM2 is associated with several neurodegenerative diseases. Results: ApoE bound to TREM2 and increased phagocytosis of apoptotic neurons by microglia. Alzheimer disease (AD)Expand
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APP processing in Alzheimer's disease
An important pathological feature of Alzheimer's disease (AD) is the presence of extracellular senile plaques in the brain. Senile plaques are composed of aggregations of small peptides calledExpand
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Chaperones increase association of tau protein with microtubules
  • Fei Dou, W. Netzer, +6 authors H. Xu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 9 January 2003
Molecular chaperones and their functions in protein folding have been implicated in several neurodegenerative diseases, including Parkinson's disease and Huntington's disease, which are characterizedExpand
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Intraneuronal Abeta42 accumulation in human brain.
Alzheimer's disease (AD) is characterized by the deposition of senile plaques (SPs) and neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated beta-amyloid (Abeta)Expand
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Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
A central question in Alzheimer's disease concerns the mechanism by which beta-amyloid contributes to neuropathology, and in particular whether intracellular versus extracellular beta-amyloid plays aExpand
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Does insulin dysfunction play a role in Alzheimer's disease?
Age-related changes in hormone levels are determinants of a variety of human diseases. Insulin is known to affect numerous brain functions including cognition and memory, and several clinical studiesExpand
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Proteolytic processing of Alzheimer’s β‐amyloid precursor protein
J. Neurochem. (2012) 120 (Suppl. 1), 9–21.
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Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.
Polar amino acids lying within three hydrophobic regions of the dopamine transporter (DAT) are analogous to those important for ligand recognition by catecholamine receptors. Possible functionalExpand
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