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Human receptors for sweet and umami taste
TLDR
It is shown that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners, and this response is enhanced by 5′-ribonucleotides, a hallmark of umami taste, which implicate the T1Rs inUmami taste and suggest that sweet and Umami taste receptors share a common subunit. Expand
Different functional roles of T1R subunits in the heteromeric taste receptors.
TLDR
This study demonstrates the different functional roles of T1R extracellular and transmembrane domains in ligand recognition and G protein coupling and the presence of multiple ligand binding sites on the sweet taste receptor. Expand
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
TLDR
An epistatic miniarray profile consisting of quantitative pairwise measurements of the genetic interactions between 743 Saccharomyces cerevisiae genes involved in various aspects of chromosome biology reveals that physical interactions fall into two well-represented classes distinguished by whether or not the individual proteins act coherently to carry out a common function. Expand
A detrimental mitochondrial-nuclear interaction causes cytoplasmic male sterility in rice
TLDR
It is reported that a new mitochondrial gene, WA352, which originated recently in wild rice, confers CMS-WA because the protein it encodes interacts with the nuclear-encoded mitochondrial protein COX11, and can be suppressed by two restorer-of-fertility genes, suggesting the existence of different mechanisms to counteract deleterious cytoplasmic factors. Expand
p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease
TLDR
Evidence for a specific role of p53 in the mitochondria-associated cellular dysfunction and behavioral abnormalities of Huntington's disease is presented and findings suggest that p53 links nuclear and mitochondrial pathologies characteristic of HD. Expand
Molecular mechanism for the umami taste synergism
TLDR
This work proposes a cooperative ligand-binding model involving the Venus flytrap domain of T1R1, where L-glutamate binds close to the hinge region, and 5′ ribonucleotides bind to an adjacent siteClose to the opening of the flytrap to further stabilize the closed conformation. Expand
Elg1 forms an alternative RFC complex important for DNA replication and genome integrity
TLDR
The proposed Elg1‐RFC functions both in normal DNA replication and in the DNA damage response, and it is found that elg1 mutants display DNA replication defects and genome instability, including increased recombination and mutation frequencies, and minichromosome maintenance defects. Expand
A Taste Receptor Required for the Caffeine Response In Vivo
TLDR
Gr66a is the first gustatory receptor shown to be essential for caffeine-induced behavior and activity of gustatory receptors cells in vivo, and further support the role of Gr66a rather than a PDE in mediating the caffeine response. Expand
Ubiquitination and Proteasomal Degradation of the BRCA1 Tumor Suppressor Is Regulated during Cell Cycle Progression*
TLDR
Data indicate that the cell cycle-dependent pattern of BRCA1 expression is determined in part by ubiquitin-dependent proteasomal degradation. Expand
Bitter Taste Receptors Influence Glucose Homeostasis
TLDR
It is suggested that a functionally compromised TAS2R receptor negatively impacts glucose homeostasis, providing an important link between alimentary chemosensation and metabolic disease. Expand
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