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Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism
TLDR
The results suggest that berberine moderates glucose and lipid metabolism through a multipathway mechanism that includes AMP-activated protein kinase-(AMPK-) p38 MAPK-GLUT4, JNK pathway, and PPARα pathway.
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Prevalence of metabolic syndrome in a cohort of Chinese schoolchildren: comparison of two definitions and assessment of adipokines as components by factor analysis
TLDR
Central obesity is the key player in the clustering of metabolic risk factors in children, supporting the new IDF definition and the findings suggest that a common factor may underlie MetS.
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[Study on the epidemiological characteristics of diabetes mellitus and IGT in China].
A community-based survey on diabetes mellitus (DM) and impaired glucose tolerance (IGT) was carried out in 11 provinces/autonomous regions/municipalities of China from July 1995 to June 1997, using…
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Acarbose Reduces Blood Glucose by Activating miR-10a-5p and miR-664 in Diabetic Rats
TLDR
The data suggest that acarbose can improve blood glucose in diabetic rats through the MAPK pathway and can down-regulate proinflammatory factors by activating miR-10a-5p and MiR-664 in the ileum.
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[A discussion on utility and purposed value of obesity and abdomen obesity when body mass index, waist circumference, waist to hip ratio used as indexes predicting hypertension and hyper-blood…
TLDR
The utility value of predicted hypertension, hyper-blood glucose in BMI and WC seemed to be better then in WHR, and it is suggested that BMI is used as the obesity index, with the diagnostic cut-off point BMI >/= 24, and WC as the abdomen obesity index.
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Telmisartan improves kidney function through inhibition of the oxidative phosphorylation pathway in diabetic rats.
TLDR
The data suggest that telmisartan can improve kidney function in diabetic rats and the mechanism may be involved in mitochondrion oxidative phosphorylation, the PPAR-γ pathway, and the slit diaphragm.
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[Effects of vitamin D supplementation on insulin resistance in patients with type 2 diabetes mellitus].
TLDR
There are significant improvements in BMI, WC, FPG, FPI, HbA1C and HOMA-IR after supplementation, indicating vitamin D supplementation may reduce insulin resistance in T2DM.
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Elevated Plasma SPARC Levels Are Associated with Insulin Resistance, Dyslipidemia, and Inflammation in Gestational Diabetes Mellitus
TLDR
SPARC levels are correlated significantly with inflammation and may also be correlated with dyslipidemia and represent an independent determinant of insulin resistance in late pregnancy, indicating a potential role of SPARC in the pathophysiology of GDM.
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Attenuating effect of Fufang Xueshuantong Capsule on kidney function in diabetic nephropathy model
TLDR
The data suggest that FXST can moderate kidney function in DN rats, and the mechanism may involve the BMP2–TGFβ–CTGF pathway, CYP2C23 and podocyte proteins.
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miR-375 and miR-30d in the Effect of Chromium-Containing Chinese Medicine Moderating Glucose Metabolism
TLDR
Through target gene analysis and real-time PCR verification, it is found that these miRNAs, especially miR-375 and miD-30d, can stimulate insulin secretion in islet and improve blood glucose in diabetic rats.
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