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Clinical Implications of CNS Penetration of Antiretroviral Drugs
The CNS serves as an important sanctuary site for HIV replication. The presence of HIV in this compartment may contribute to neurological complications in individuals infected with HIV. UnderstandingExpand
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Pharmacokinetic Enhancement of Protease Inhibitor Therapy
Combination antiretroviral therapy with two or more protease inhibitors has become the standard of care in the treatment of HIV infection. Dual protein inhibitor (PI) regimens, such asExpand
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Effects of Grapefruit Juice on Pharmacokinetic Exposure to Indinavir in HIV‐Positive Subjects
The objective of this study was to determine the effects of double‐strength grapefruit juice on gastric pH and systemic bioavailability of indinavir in HIV‐infected subjects receiving indinavir.Expand
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Symptomatic Hyperbilirubinemia with Indinavir/Ritonavir—Containing Regimen
OBJECTIVE: To report a case of symptomatic hyperbilirubinemia resulting from the addition of ritonavir to an indinavir-containing antiretroviral regimen. CASE SUMMARY: A 27-year-old white womanExpand
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Discontinuation of prophylaxis for HIV-associated opportunistic infections in the era of highly active antiretroviral therapy.
PURPOSE The rationale for recent changes in guidelines for the prevention of opportunistic infections (OIs) in HIV-infected persons is discussed. SUMMARY The epidemiology of AIDS has changedExpand
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Oven melting encapsulization of hypodermic needles by syringes
The results of a study to determine the time and temperature conditions necessary to melt standard injection syringes are presented. The polypropylene syringes are melted to form a solid block ofExpand
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Perceptions of Southwestern African-Americans with regard to safety and the police: An exploratory study
The purpose of this study was to investigate perceptions of African-Americans in the Southwest with regard to police, crime, and safety. As part of a larger study of a 12,500 sample of White, Asian,Expand