• Publications
  • Influence
Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis
  • Y. Cui, C. Yu, +30 authors R. Yang
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 27 December 2012
The genetic diversity of Yersinia pestis, the etiologic agent of plague, is extremely limited because of its recent origin coupled with a slow clock rate. Here we identified 2,326 SNPs from 133Expand
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The DNA Methylome of Human Peripheral Blood Mononuclear Cells
Analysis across the genome of patterns of DNA methylation reveals a rich landscape of allele-specific epigenetic modification and consequent effects on allele-specific gene expression.
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Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly
Here we use whole-genome de novo assembly of second-generation sequencing reads to map structural variation (SV) in an Asian genome and an African genome. Our approach identifies small- andExpand
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Whole-genome sequencing of Oryza brachyantha reveals mechanisms underlying Oryza genome evolution
The wild species of the genus Oryza contain a largely untapped reservoir of agronomically important genes for rice improvement. Here we report the 261-Mb de novo assembled genome sequence of OryzaExpand
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Single-base-resolution methylomes of populus trichocarpa reveal the association between DNA methylation and drought stress
BackgroundDNA methylation is an important biological form of epigenetic modification, playing key roles in plant development and environmental responses.ResultsIn this study, we examined single-baseExpand
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An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins
DNA methylation has a great potential for understanding the aetiology of common complex traits such as Type 2 diabetes (T2D). Here we perform genome-wide methylated DNA immunoprecipitation sequencingExpand
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Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing
BackgroundReduced representation bisulfite sequencing (RRBS) was developed to measure DNA methylation of high-CG regions at single base-pair resolution, and has been widely used because of itsExpand
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Hypermethylation in the ZBTB20 gene is associated with major depressive disorder
BackgroundAlthough genetic variation is believed to contribute to an individual’s susceptibility to major depressive disorder, genome-wide association studies have not yet identified associationsExpand
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DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation
BackgroundThe association of in vitro fertilisation (IVF) and DNA methylation has been studied predominantly at regulatory regions of imprinted genes and at just thousands of the ~28 million CpGExpand
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An atlas of DNA methylomes in porcine adipose and muscle tissues.
  • M. Li, H. Wu, +46 authors R. Li
  • Biology, Medicine
  • Nature communications
  • 22 May 2012
It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the Expand
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