H. Wolfson

Publications206
h-index67
Citations18,207
Highly Influential Citations773
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PatchDock and SymmDock: servers for rigid and symmetric docking
TLDR
Two freely available web servers for molecular docking that perform structure prediction of protein–protein and protein–small molecule complexes and the SymmDock method predicts the structure of a homomultimer with cyclic symmetry given theructure of the monomeric unit are described. Expand
Shape complementarity at protein–protein interfaces
TLDR
A matching algorithm using surface complementarity between receptor and ligand protein molecules is outlined, and it is shown that out of the 16 protein‐protein complexes tried, 15 were successfully docked, including two immunoglobulins. Expand
Geometric Hashing: A General And Efficient Model-based Recognition Scheme
  • Y. Lamdan, H. Wolfson
  • Computer Science
  • [ Proceedings] Second International Conference on…
  • 5 December 1988
TLDR
A general method for model-based object recognition in occluded scenes is presented based on geometric hashing, which stands out for its efficiency and applications both in 3-D and 2-D. Expand
Efficient Unbound Docking of Rigid Molecules
TLDR
A new algorithm for unbound (real life) docking of molecules, whether protein-protein or protein-drug, carrying out rigid docking, with surface variability/flexibility implicitly addressed through liberal intermolecular penetration is presented. Expand
FireDock: a web server for fast interaction refinement in molecular docking†
TLDR
The FireDock web server, presented here, is the first web server for flexible refinement and scoring of protein–protein docking solutions and includes optimization of side-chain conformations and rigid-body orientation and allows a high-throughput refinement. Expand
FireDock: Fast interaction refinement in molecular docking
TLDR
FireDock's prediction results are comparable to current state‐of‐the‐art refinement methods while its running time is significantly lower, and its refinement procedure significantly improves the ranking of the rigid‐body PatchDock algorithm for these cases. Expand
Protein structure fitting and refinement guided by cryo-EM density.
TLDR
A heuristic optimization that relies on a Monte Carlo search, a conjugate-gradients minimization, and simulated annealing molecular dynamics is applied to a series of subdivisions of the structure into progressively smaller rigid bodies. Expand
Context-free attentional operators: The generalized symmetry transform
TLDR
An attention operator based on the intuitive notion of symmetry, which generalized many of the existing methods of detecting regions of interest is presented, a low-level operator that can be applied successfully without a priori knowledge of the world. Expand
Geometric hashing: an overview
Geometric hashing, a technique originally developed in computer vision for matching geometric features against a database of such features, finds use in a number of other areas. Matching is possible… Expand
A method for simultaneous alignment of multiple protein structures
TLDR
It is their residue sequence order‐independence that allows application of MultiProt to derive multiple alignments of binding sites and of protein‐protein interfaces, making MultiProt an extremely useful structural tool. Expand
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