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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.
A monoclonal antibody to the microtubule-associated protein tau (tau) labeled some neurofibrillary tangles and plaque neurites, the two major locations of paired-helical filaments (PHF), in AlzheimerExpand
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Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
Microtubule-associated protein tau was purified from bovine brain microtubules by either (1) phosphocellulose chromatography, (2) heat treatment at pH 6.4, (3) heat treatment at pH 2.7, (4) heatExpand
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Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins.
Antibody response in mice to scrapie-associated fibril proteins (protease-resistant proteins [PrPs]) was generated to different epitopes depending on the source of antigen. Mice responded differentlyExpand
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Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease.
BACKGROUND In brains with AD, Abeta is a major component of diffuse plaques. Previous reports showed that CSF Abeta42 levels were lower in patients with AD than in controls. Although studies showedExpand
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Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
One hundred brains of patients with Down's syndrome(DS) who died in insstitutions for chronic care were exemined for clinicopathological correlation of Alzheimer's disease. Fifty‐one were below andExpand
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Presenile dementia. Clinical aspects and evaluation of cerebrospinal fluid dynamics.
Data from 30 patients with presenile dementia are reported regarding history, clinical findings with special assessment of mental status; electroencephalography; and cerebral blood flow for tenExpand
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Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer disease.
The hippocampal formations of 13 subjects with severe Alzheimer disease [AD; Global Deterioration Scale (GDS) stage 7] and of 5 age-matched subjects without symptoms of dementia were reconstructedExpand
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The “Nonamyloidogenic” p3 Fragment (Amyloid β17-42) Is a Major Constituent of Down's Syndrome Cerebellar Preamyloid*
Down's syndrome (DS) patients show accelerated Alzheimer's disease (AD) neuropathology, which consists of preamyloid lesions followed by the development of neuritic plaques and neurofibrillaryExpand
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Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease.
Mutations in the amyloid precursor protein and presenilin 1 and 2 genes result in elevated plasma levels of the amyloid beta-peptide species terminating at amino acid residue 42 (A beta1-42). In aExpand
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