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The Catalog of Human Hair Keratins
In situ hybridization and immunohistochemical expression studies on scalp follicles show that two hair keratins define the early stage of hair differentiation, i.e. hHa5 expression in hair matrix and hHa4/hHa2 coexpression in the early hair cuticle cells.
A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle.
Evidence is provided that, together with Henle cells, Flügelzellen ensure the maintenance of a continuous desmosomal anchorage of the companion layer along the entire inner root sheath unit provides an optimal molding and guidance of the growing hair shaft.
A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle.
It is shown that the new cytokeratin K6hf is exclusively expressed in the so-called "companion layer" of the hair follicle, a single layered band of flat and vertically oriented cells between the cuboidal ORS cells and the IRS that stretches from the lowermost bulb region to the isthmus of the follicle.
K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle.
Evidence that Flügelzellen penetrate theHenle layer actively and may play a role in conferring plasticity and resilience to the otherwise rigid upper Henle layer is provided.
HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression*
The data speak for a direct involvement of HOXC13 in the control of hair keratin expression during early trichocyte differentiation.
Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-associated Protein (KAP) Genes on Chromosome 21q22.1*
Both systematic cDNA isolation studies from an arrayed scalp cDNA library and in situ hybridization expression studies of all of the KAP genes identified in the 21q22.1 region revealed varying degrees and regions of expression of 11 members of the high tyrosine-glycine genes and 6 members ofThe high sulfur K AP genes in the hair forming compartment.
Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.
This study describes, in addition to the genomic sequencing of the K2p gene and the bioinformatic identification of four keratin pseudogenes, the characterization of cDNA corresponding to three previously undescribed keratin genes K1b, K6l, and Kb20, as well as cDNA sequences for the previously described Keratin genes hHb2, hHB4, andK3.
Hair follicle-specific keratins and their diseases.
Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study.
Diffuse partial woolly hair can be associated with loose anagen hair syndrome, and a keratin mutation, E337K in K6HF, was possibly causative in 3 of the 9 families studied.