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Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]WAY-100635
The selective labeling of 5-HT1A receptors with [3H]WAY-100635 clearly show that this compound is useful for further studies of the human 5- HT1a receptor subtype in vivo and provides a strong basis for expecting [11C]Way- 100635 to behave as a highly selective radioligand in vivo. Expand
Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum.
It is concluded that typical and non-benzamide atypical antipsychotic drugs increase extracellular dopamine in the medial prefrontal cortex via a synergistic interaction by blocking 5-HT(2) as well as dopamine D(2), and the position of the benzamides is discussed. Expand
Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions.
Even though the EC/MS/MS system is not able to mimic all oxidations performed by cytochrome P450, valuable information can be obtained concerning the sensitivity of the substrate towards oxidation and in which position of the molecule oxidations are likely to take place. Expand
Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: A comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride
PET measurements of stimulant‐induced dopamine (DA) release are typically performed with antagonist radioligands that bind to both the high‐ and low‐affinity state of the receptor. In contrast, anExpand
Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 receptor ligand.
In rats R-(+)-7-OH-DPAT dose dependently decreased dopamine release and induced yawning, while sniffing behaviour occurred at the highest dose tested (1000 nmol/kg), suggesting the possibility that the inhibition of dopamineRelease and the elicitation of yawning are mediated by dopamine D3 receptors. Expand
Augmentation of SSRI Effects on Serotonin by 5-HT2C Antagonists: Mechanistic Studies
Investigation of the mechanism through which an augmentation approach involving selective serotonin reuptake inhibitors (SSRIs) in combination with compounds that focus on antagonism of inhibitory serotonin receptors suggested that the release of extracellular serotonin in ventral hippocampus may be controlled by (an)other brain area(s). Expand
Acute and chronic effects of citalopram on postsynaptic 5‐hydroxytryptamine1A receptor‐mediated feedback: a microdialysis study in the amygdala
Data suggest an involvement of postsynaptic 5‐HT1A receptor‐mediated feedback in the amygdala, which diminishes following chronic citalopram treatment, which is larger than in untreated animals. Expand
Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.
A number of the 2-aminotetralins showed high affinity for both the D2 and the D3 DA receptors, as exemplified by compounds 11-15 and 21-26, while some had a reasonable selectivity for the DA D3 receptors. Expand
Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells.
Results indicate that [3H]PD 128907 is a new, highly selective D3 receptor ligand with high specific activity, high specific binding and low non-specific binding and therefore should be useful for further characterizing the DA D3 receptors. Expand
Analytical Aspects of Phytotherapeutic Valerian Preparations
A high performance liquid chromatographic method combined with diode array detection is described by which the valerian constituents valtrate, isovaltrate, acevaltrate, didrovaltrate,Expand