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Local energy depletion in the basal forebrain increases sleep
TLDR
It is shown that energy depletion in localized brain areas can generate sleep, and the energy depletion model of sleep induction could be applied to in vitro research into the cellular mechanisms of prolonged wakefulness.
Histamine Release in the Basal Forebrain Mediates Cortical Activation through Cholinergic Neurons
TLDR
Results show that activation of the cholinergic BF by histamine is important in sustaining a high level of cortical activation, and that a lack of activation ofThe basal forebrain by Histamine may be important in initiating and maintaining nonrapid eye movement sleep.
Sleep, its regulation and possible mechanisms of sleep disturbances
TLDR
This review covers the current theories on the function of normal sleep and describes current knowledge on the physiologic effects of sleep loss providing insights into the basic mechanisms of the regulation of wakefulness and sleep creating a theoretical background for understanding different disturbances of sleep.
Basal Forebrain Lactate Release and Promotion of Cortical Arousal during Prolonged Waking Is Attenuated in Aging
TLDR
The results suggest that an age-related attenuation in BF function reduces cortical arousal during prolonged waking, as the quality of waking is important in regulating the subsequent sleep, and reduced cortex arousal during SD may contribute to the age- related reduction in sleep intensity.
Cortical Excitability and Activation of TrkB Signaling During Rebound Slow Oscillations Are Critical for Rapid Antidepressant Responses
TLDR
The results support a hypothesis that transient cortical excitability and the subsequent regulation of TrkB and GSK3β signaling during homeostatic emergence of slow oscillations are critical components for rapid antidepressant responses.
Brief Isoflurane Anesthesia Produces Prominent Phosphoproteomic Changes in the Adult Mouse Hippocampus.
TLDR
The potential of quantitative phosphoproteomics to study the mechanisms of anesthetics (and other drugs) in the mammalian brain is demonstrated and how already a relatively brief anesthesia produces pronounced phosphorylation changes in multiple proteins in the central nervous system is revealed.
Introduction of real patients into problem-based learning in preclinical first-year anatomy curriculum
TLDR
Real patient triggers motivate students to learn basic medical sciences and ways to present real patients to students should be considered in medical curricula from early on.
Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects.
TLDR
Even when the consequences of adverse early-life events are not observed in tests for anxiety and depression, they leave a molecular mark in the brain, which can act as a vulnerability factor for psychopathologies in later life.
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