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Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder.
TLDR
Bilateral deep brain stimulation of the nucleus accumbens may be an effective and safe treatment for treatment-refractory OCD and no permanent adverse events were reported. Expand
Dysfunctional Reward Circuitry in Obsessive-Compulsive Disorder
TLDR
This first functional imaging study to investigate explicitly reward circuitry in OCD shows attenuated reward anticipation activity in the nucleus accumbens compared with healthy control subjects, and supports the conceptualization of OCD as a disorder of reward processing and behavioral addiction. Expand
Thinner prefrontal cortex in veterans with posttraumatic stress disorder
TLDR
Reduced cortical thickness in the bilateral superior and middle frontal gyri, the left inferior frontal gyrus, and the left superior temporal gyrus revealed in veterans with PTSD may correspond to functional abnormalities observed in patients with PTSD. Expand
Autonomic and Neuroendocrine Responses to a Psychosocial Stressor in Adults with Autistic Spectrum Disorder
Objective of the study was to replicate in adults our previous findings of decreased heart rate and normal endocrine responses to stress in autistic children and to elucidate the discrepancy betweenExpand
Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review.
TLDR
All English-language, human subject, data driven, pharmacological and non-pharmacological challenge studies pertaining to the HPA axis, and in vitro leukocyte glucocorticoid receptor studies in adult PTSD subjects are reviewed. Expand
The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol
TLDR
Testing whether alpha-lactalbumin, a whey protein with a high tryptophan content, may increase the plasma Trp-LNAA ratio and reduce depressive mood and cortisol concentrations in stress-vulnerable subjects under acute stress found it improved coping ability. Expand
Consensus statement on social anxiety disorder from the International Consensus Group on Depression and Anxiety.
TLDR
The consensus statement underlines the importance of recognizing social anxiety disorder and provides recommendations on how it may be distinguished from other anxiety disorders and proposes definitions for response and remission and considers appropriate management strategies. Expand
Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
TLDR
In vivo evidence for abnormalities in the binding potential of the dopamine D(2) receptor is provided, which suggest the direct involvement of the dopaminergic system in the pathophysiology of OCD. Expand
Glutamate and anxiety
TLDR
It can be expected that selective modulators of glutamate activity will be of great clinical significance for the treatment of anxiety disorders. Expand
A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors.
TLDR
The results of this study show that quetiapine in addition to an SRI is beneficial for patients with OCD who do not respond to SRI treatment alone. Expand
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