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Physical activity in patients with COPD
TLDR
Physical activity is reduced in patients with chronic obstructive pulmonary disease from Global Initiative for Chronic Obstructive Lung Disease stage II/ body mass index, airway obstruction, dyspnoea, exercise capacity score 1.
Withdrawal of inhaled glucocorticoids and exacerbations of COPD.
TLDR
In patients with severe COPD receiving tiotropium plus salmeterol, the risk of moderate or severe exacerbations was similar among those who discontinued inhaled glucocorticoids and those who continued glucocORTicoid therapy, but there was a greater decrease in lung function during the final step of glucoc Corticoid withdrawal.
Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2–4)
TLDR
Significant improvements in lung function and health-related quality of life with once-daily tiotropium+olodaterol FDC versus mono-components over 1 year in patients with moderate to very severe COPD are demonstrated.
The metabolic syndrome in patients with chronic bronchitis and COPD: frequency and associated consequences for systemic inflammation and physical inactivity.
TLDR
Almost one-half of the patients with CB/COPD had coexisting metabolic syndrome, with a slightly lower frequency in patients with severe COPD, which is associated with an increase in the levels of some systemic inflammatory markers and physical inactivity, independent of lung function impairment.
An official European Respiratory Society statement on physical activity in COPD
This European Respiratory Society (ERS) statement provides a comprehensive overview on physical activity in patients with chronic obstructive pulmonary disease (COPD). A multidisciplinary Task Force
Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study.
TLDR
Higher values of systemic inflammation and left cardiac dysfunction are associated with reduced physical activity in patients with COPD.
Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms.
  • S. Togo, O. Holz, S. Rennard
  • Medicine, Biology
    American journal of respiratory and critical care…
  • 1 August 2008
TLDR
Fibroblasts from individuals with COPD have reduced capability to sustain tissue repair, which suggests that this may be one mechanism that contributes to the development of emphysema.
Decreasing cardiac chamber sizes and associated heart dysfunction in COPD: role of hyperinflation.
TLDR
An increasing rate of COPD severity is associated with a decreasing heart size, and hyperinflation could play an important role regarding heart size and heart dysfunction in patients with COPD.
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