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SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas
Lineage-survival oncogenes are activated by somatic DNA alterations in cancers arising from the cell lineages in which these genes play a role in normal development. Here we show that a peak of… Expand
Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma.
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in… Expand
Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.
Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that… Expand
Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers
Whole-genome analysis approaches are identifying recurrent cancer-associated somatic alterations in noncoding DNA regions. We combined somatic copy number analysis of 12 tumor types with… Expand
Fusobacterium nucleatum and T Cells in Colorectal Carcinoma.
IMPORTANCE Evidence indicates a complex link between gut microbiome, immunity, and intestinal tumorigenesis. To target the microbiota and immunity for colorectal cancer prevention and therapy, a… Expand
SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas.
- H. Watanabe, Q. Ma, +17 authors A. Bass
- Medicine, Biology
- The Journal of clinical investigation
- 1 April 2014
The transcription factor SOX2 is an essential regulator of pluripotent stem cells and promotes development and maintenance of squamous epithelia. We previously reported that SOX2 is an oncogene and… Expand
A New Procedure
We experienced a new procedure of the decompression of thoracic OPLL. This procedure is as follows. The vertebral body and rib were exposed by extrapleural approach. First a proximal side of the rib… Expand
Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.
UNLABELLED As a master regulator of chromatin function, the lysine methyltransferase EZH2 orchestrates transcriptional silencing of developmental gene networks. Overexpression of EZH2 is commonly… Expand
Deeper Sentiment Analysis Using Machine Translation Technology
We developed a high-precision sentiment analysis system at a low development cost, by making use of an existing transfer-based machine translation engine. Expand