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Cerebral ischemia model with conscious mice. Involvement of NMDA receptor activation and derangement of learning and memory ability.
TLDR
The decline in cognition as observed with ischemic mice is due to the temporal and reversible derangement of their neuronal networks, and the model could be used to assess the efficiency of drugs with high clinical predictivity. Expand
[Inhibitory effects of naturally occurring furan fatty acids on hemolysis of erythrocytes induced by singlet oxygen].
TLDR
The inhibitory effects of F acids on hemolysis were compared with those of known singlet oxygen quenchers such as dimethylfuran, alpha-tocopherol, ascorbic acid and uric Acid and F acids were found to be the most effective quencher. Expand
[Intraventricular administration of central stimulants and animal behavior].
[A new system for the measurement and analysis of motor activity in mice: effect of several central stimulants].
TLDR
The results suggest that this apparatus is able to detect characteristic changes in spontaneous motor activity produced by central stimulants and may be useful for analyzing drug-induced motor activity in mice in more detail. Expand
[Separation of Thomsen-Friedenreich (T) antigen and N antigen precursor glycoproteins from perchloric acid-soluble fraction of cyst fluid of human ovarian clear cell carcinoma and their some chemical
TLDR
Reactivities against various hemagglutinins of these four fractions suggest that DEAE-Fr. Expand
[Some chemical and serological properties of perchloric acid-soluble glycoproteins separated from ascitic fluid of a patient with metastatic omentum tumor from ovarian cancer].
One mol perchloric acid-soluble fraction (PASF) obtained from ascitic fluid of a patient (blood group B) with metastatic omentum tumor from ovarian cancer was a glycoprotein fraction containing 35.4%Expand
Methamphetamine- and apomorphine-induced changes in spontaneous motor activity using a new system to detect and analyze motor activity in mice.
TLDR
Results indicate the new system to be quite useful to detect and analyze drug-induced changes in spontaneous motor activity and dependence on the dosages of methamphetamine and apomorphine. Expand
Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis.
TLDR
Seventeen thiopaeonimetabolin-I adducts were obtained as mixtures of diastereoisomers after incubation of paeoniflorin with Lactobacillus brevis in the presence of various thiols and showed dose-dependent prolongation of latencies of clonic and tonic convulsions. Expand
[Availability of 2VO rats as a model for chronic cerebrovascular disease].
  • M. Nanri, H. Watanabe
  • Chemistry, Medicine
  • Nihon yakurigaku zasshi. Folia pharmacologica…
  • 1 February 1999
TLDR
The 2VO rat appears to be a useful model for investigating the pathophysiology of human dementia and to elucidate the therapeutic potential of drugs for this disease. Expand
A long-lasting potentiation of calmodulin-mediated chloride channel activity without a mediation of protein kinase C in Xenopus oocytes injected with rat brain mRNA.
TLDR
Observations indicate that the endogenous calmodulin/Cl- channel system may memorize an over-threshold increase in the intracellular Ca2+ concentration and potentiate the Ca2(+)-sensitiveness of the Cl- channel. Expand
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