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Identification of CD24 as a Cancer Stem Cell Marker in Human Nasopharyngeal Carcinoma
Cancer stem cells (CSCs) represent a unique sub-population of tumor cells with the ability to initiate tumor growth and sustain self-renewal. Although CSC biomarkers have been described for variousExpand
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Synthesis, Characterization and the Antioxidative Activity of Copper(II), Zinc(II) and Nickel(II) Complexes with Naringenin
New complexes of Cu(II), Zn(II) and Ni(II) with naringenin have been synthesized and characterized on the basis of elemental analyses, molar conductivities, 1H-n.m.r., i.r. spectra, u.v. spectra,Expand
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A laccase with antiproliferative activity against tumor cells from an edible mushroom, white common Agrocybe cylindracea.
A laccase, with HIV-1 reverse transcriptase inhibitory activity (IC(50)=12.7 μM) and antiproliferative activity against HepG2 cells (IC(50)=5.6 μM) and MCF7 cells (IC(50)=6.5 μM), was purified fromExpand
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The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.
The three Pim kinases are a small family of serine/threonine kinases regulating several signaling pathways that are fundamental to tumorigenesis. As such, the Pim kinases are a very attractive targetExpand
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Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Cyclin-dependent kinase 5 (CDK5) is a serine/threonine protein kinase and its deregulation is implicated in a number of neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateralExpand
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The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.
High levels of Pim expression have been implicated in several hematopoietic and solid tumor cancers. These findings suggest that inhibition of Pim signaling by a small molecule Pim-1,2 inhibitorExpand
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Depressive symptoms in Taiwanese women during the peri- and post-menopause years: associations with demographic, health, and psychosocial characteristics.
OBJECTIVE The purpose of this study was to evaluate the prevalence of depressive symptoms in peri- and post-menopausal Taiwanese women, and to investigate the relation between depressive symptoms andExpand
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Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.
KRASG12C has emerged as a promising target in the treatment of solid tumors. Covalent inhibitors targeting the mutant cysteine-12 residue have been shown to disrupt signaling by thisExpand
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Intermittent hypoxia enhances the tumor programmed death ligand 1 expression in a mouse model of sleep apnea.
Background As a hallmark of obstructive sleep apnea (OSA), intermittent hypoxia (IH) promotes tumor progress. The high expression of programmed death 1 and programmed death ligand 1 (PD-L1) in tumorExpand
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Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.
Based on the previously reported clinical candidate, AMG 517 (compound 1), a series of related piperazinylpyrimidine analogues were synthesized and evaluated as antagonists of the vanilloid 1Expand
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