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Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation.
Studies on the mechanism of apoptosis in this laboratory support a model in which signal transduction involving caspase 3 leads to activation of a serine protease called Mr 24,000 apoptotic protease… Expand
Chemotherapeutic drug activation of the AP24 protease in apoptosis: requirement for caspase 3-like-proteases.
- S. C. Wright, U. Schellenberger, H. Wang, Y. Wang, D. Kinder
- Biology, Medicine
- Biochemical and biophysical research…
- 28 April 1998
AP24 is a serine protease that is activated during TNF or UV light-induced apoptosis and stimulates DNA fragmentation in isolated nuclei. The present study determined whether apoptosis induced by… Expand