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Decreased expression of N-methyl-d-aspartate (NMDA) receptors in rat dorsal root ganglion following complete Freund's adjuvant-induced inflammation: an immunocytochemical study for NMDA NR1 subunit
The changes in expression of NMDA NR1, an essential functional subunit of N-methyl-D-aspartate (NMDA) receptors, were examined in the rat lumbar dorsal root ganglion (DRG) by immunocytochemical… Expand
Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-α/NF-κB pathway.
BACKGROUND Reactive oxygen species (ROS) play a pivotal role in neointima hyperplasia after balloon injury. Molecular hydrogen has emerged as a novel antioxidant and has been proven effective in… Expand
1,25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the β-catenin/TCF4/GSK-3β/mTOR pathway
- H. Wei, H. Qu, H. Wang, Baolan Ji, H. Deng
- Biology, Medicine
- The Journal of Steroid Biochemistry and Molecular…
- 1 April 2017
Diabetic cardiomyopathy (DCM) can increase the risk of heart failure and death in diabetic patients. However, no effective approaches are available to prevent its progression and development. Studies… Expand
Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.
Robo2 is the cell surface receptor for the repulsive guidance cue Slit and is involved in axon guidance and neuronal migration. Nephrin is a podocyte slit-diaphragm protein that functions in the… Expand
Silent information regulator 1 (SIRT1) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway.
- W. Li, Dayong Du, +7 authors Yuntian Li
- Medicine, Biology
- International journal of clinical and…
- 1 March 2015
Silent information regulator 1 (SIRT1) mediates many effects of caloric restriction (CR) on an organism's lifespan and metabolic pathways. Recent reports have also emphasized its role in vascular… Expand
PI3K/Akt/FoxO: a novel participant in signal transduction in bone cells under mechanical stimulation
FoxO (forkhead box O) transcription factors, one of the main downstream mediators of PI3K (phosphatidylinositol‐3 kinase)/Akt [also known as PKB (protein kinase B)] signal transduction pathway, play… Expand
Lipopolysaccharide increases IL‐6 secretion via activation of the ERK1/2 signaling pathway to up‐regulate RANKL gene expression in MLO‐Y4 cells
Lipopolysaccharide (LPS) plays an important role in bone resorption, which involves numerous cytokines through various signaling pathways. RANKL and interleukin (IL)‐6 are two important cytokines… Expand
Gene expression patterns of osteocyte‐like MLO‐Y4 cells in response to cyclic compressive force stimulation
- W. Chen, H. Qing, Yun He, J. Wang, Zhimin Zhu, H. Wang
- Biology, Medicine
- Cell biology international
- 1 May 2010
Although osteocytes have long been regarded as mechanosensors for translating mechanical signals into biochemical signals to regulate the other bone cells, the global gene expression patterns and… Expand
[Platelet derived growth factor receptor β over-expression in endothelial progenitor cells promote reendothelialization after vascular injury].
- H. Wang, H. Huang, Y. Yin, M. Deng, Huali Kang, L. Huang
- Chemistry, Medicine
- Zhonghua xin xue guan bing za zhi
- 1 March 2014
OBJECTIVE To observe the effect of platelet derived growth factor receptor β (PDGFR-β) transfected endothelial progenitor cells (EPCs) on vascular regeneration. METHODS Spleen-derived mononuclear… Expand
c-Fos expression in NMDA receptor-contained neurons in spinal cord in a rat model of inflammation: a double immunocytochemical study
Double-labeling techniques were used to demonstrate the nociceptive activation of NMDA receptor-contained neurons in spinal dorsal horn by using c-Fos immunoreactivity as an indicator of this… Expand